DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Btk and SYK

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_003168.2 Gene:SYK / 6850 HGNCID:11491 Length:635 Species:Homo sapiens


Alignment Length:636 Identity:167/636 - (26%)
Similarity:265/636 - (41%) Gaps:180/636 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   267 GGVGGGLG---------GGGSLGLGGG------------------GGGGGSCTPTSL-----QPQ 299
            ||:..||.         ||.:|.:..|                  .||....:|..|     |..
Human    32 GGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQES 96

  Fly   300 SSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDN--SHFVKLVVALYPFKAIEGGDLS 362
            ..|....:.|           .|.|.|:.....|....|:|  ..:||....|.. :|:|...:|
Human    97 DGLVCLLKKP-----------FNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQG-QALEQAIIS 149

  Fly   363 LEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQG 427
            .:...|                             |..|....|:..|:.|.:||:.:|.::..|
Human   150 QKPQLE-----------------------------KLIATTAHEKMPWFHGKISREESEQIVLIG 185

  Fly   428 DK-EGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRH- 490
            .| .|.|::|.....|.|.|.|   :.:..|.||.|.::...:..:.|....:|:..|:.::.: 
Human   186 SKTNGKFLIRARDNNGSYALCL---LHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYK 247

  Fly   491 -------------------------------------NSGGLACRLKS----SPCDRPVPPTAGL 514
                                                 ::||:..|:||    .|..|...|..|.
Human   248 ADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGN 312

  Fly   515 SHDK-------------W--------------------------EIHPME------LMLME--EL 532
            ..:.             |                          ||.|.|      |:.:|  ||
Human   313 RQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKEL 377

  Fly   533 GSGQFGVVRRG--KWRGSIDT-AVKMMKEGTMS---EDDFIEEAKVMTKLQHPNLVQLYGVCSKH 591
            |||.||.|::|  :.:..:.| |||::|.....   :|:.:.||.||.:|.:|.:|::.|:|...
Human   378 GSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAE 442

  Fly   592 RPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVG 656
            ..: :|.|..:.|.|..||:::......|   ::::..|||.||.|||..|::||||||||.|:.
Human   443 SWM-LVMEMAELGPLNKYLQQNRHVKDKN---IIELVHQVSMGMKYLEESNFVHRDLAARNVLLV 503

  Fly   657 SENVVKVADFGLARYVLDDQ--YTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTC 719
            :::..|::||||::.:..|:  |.:....|:|:||..||.:||.:||||||||::||||||.|:.
Human   504 TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSY 568

  Fly   720 GKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAF 770
            |:.||..:|.:||...:::|..:..|..|.:|:||:|.|||::..|.||.|
Human   569 GQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGF 619

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 5/52 (10%)
SH2_Tec_family 403..505 CDD:198188 28/144 (19%)
PTKc_Tec_like 521..778 CDD:173637 104/266 (39%)
SYKNP_003168.2 SH2_N-SH2_Zap70_Syk_like 13..116 CDD:198191 18/94 (19%)
Interdomain A 108..167 16/88 (18%)
SH2_C-SH2_Syk_like 164..262 CDD:198264 22/100 (22%)
Interdomain B 260..370 14/109 (13%)
PTKc_Syk 375..631 CDD:133247 99/249 (40%)
Blue background indicates that the domain is not in the aligned region.

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