DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and SRMS

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_543013.1	Gene:	SRMS / 6725	HGNCID:	11298	Length:	488	Species:	Homo sapiens

Alignment Length:	467	Identity:	170/467 - (36%)
Similarity:	248/467 - (53%)	Gaps:	23/467 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 GGIPTPGTPNS-----------KAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEH 378
            ||.|..|||.|           .|:..|.|.:|.:|||.|.|..||:||:.:......:::...:
Human    23 GGEPDHGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCALEEGGGY 87

  Fly   379 WWKVK-DALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKE-GCFVVRKS-ST 440
            .:..: ....:.|.:|..:|...:...|....||...:||.:|:.||.....| |.|::|.| |:
Human    88 IFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESS 152

  Fly   441 KGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCD 505
            .|.|:||:..   |:.|.||.:...|....||.:......:.:|:.|::.|     .:|..:|..
Human   153 LGGYSLSVRA---QAKVCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKAN-----WKLIQNPLL 209

  Fly   506 RPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEA 570
            :|..|......|.||....|..|..:||.|.||.|..|.|.||:..|:|::|...|...|..:|.
Human   210 QPCMPQKAPRQDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEI 274

  Fly   571 KVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGM 635
            :.:..|:|..|::|:.|||...|:|||||.|:.|:|..:|...|...: .:..||....||::||
Human   275 QTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRAL-RLPPLLGFACQVAEGM 338

  Fly   636 TYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRF 700
            :|||....:||||||||.||......|||||||||.:.||.|:.|..:|.|:||..||..||..|
Human   339 SYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVF 403

  Fly   701 SSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPE 765
            |.|||||::|||:.|:||.|:.||..:.|.|.::::.||..|.:|.:|..|:|.:|..||...||
Human   404 SQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPE 468

  Fly   766 ERPAFRVLMDQL 777
            |||:|..|.::|
Human   469 ERPSFATLREKL 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	13/53 (25%)
		SH2_Tec_family	403..505	CDD:198188	30/103 (29%)
		PTKc_Tec_like	521..778	CDD:173637	112/257 (44%)
		Pkinase_Tyr	526..777	CDD:285015	110/250 (44%)
SRMS	NP_543013.1	SH3_Srms	55..109	CDD:212780	13/53 (25%)
		SH2	119..197	CDD:301589	25/80 (31%)
		PTKc_Srm_Brk	223..483	CDD:133248	114/259 (44%)
		STYKc	232..480	CDD:214568	110/248 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820