DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Btk29A and BMX

DIOPT Version :9

Sequence 1:NP_001097121.1 Gene:Btk29A / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_001712.1 Gene:BMX / 660 HGNCID:1079 Length:675 Species:Homo sapiens


Alignment Length:771 Identity:284/771 - (36%)
Similarity:407/771 - (52%) Gaps:156/771 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 MVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVRLVEEATVSGEGGDP 112
            ::||:|.||:.:|.|||.|.|.|||...||::.:.::|...:|.|.:|.:|.||:  |:.|...|
Human    11 LLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKIRCVEK--VNLEEQTP 73

  Fly   113 FAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSEKERSEWIR 177
            .... ||||:.|            ::|                     .|||.|::|:.||:|::
Human    74 VERQ-YPFQIVY------------KDG---------------------LLYVYASNEESRSQWLK 104

  Fly   178 AIRQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLSRTTFGC---RAAAHWREANNNPSNGSSPAQN 239
            |:::... .|.....:||.|.:...|:.||:...:...||   .|.|:...|.|...:......:
Human   105 ALQKEIR-GNPHLLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPD 168

  Fly   240 STRSI----------SPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPT 294
            ....|          :|:||||.:|:  .:.|..:.|.                           
Human   169 RVLKIPRAVPVLKMDAPSSSTTLAQY--DNESKKNYGS--------------------------- 204

  Fly   295 SLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGG 359
              ||.||.|:..|           .|:|.                              |.|.|.
Human   205 --QPPSSSTSLAQ-----------YDSNS------------------------------KKIYGS 226

  Fly   360 DLSLEKNAEYEVIDDSQEHWWKVKDALG---------------NVGYIPS--NYVKPKALL---- 403
            ..:.  |.:|...:|..: ||:|:....               ||.:..|  ::..|::..    
Human   227 QPNF--NMQYIPREDFPD-WWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEE 288

  Fly   404 -GLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKV---PQSHVKHYHIKQ 464
             .|:.|:|:.|::||.::|.||:|..|||.|:||.||..|:||:||.:|.   .:..|||||:..
Human   289 ENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHT 353

  Fly   465 NARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLK---SSPCDRPVPPTAGLSHDKWEIHPMEL 526
            ||..:.||:|.:|.::||.||:||:|||.|:..||:   |:..:: ||.:..|.:..||:...|:
Human   354 NAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANK-VPDSVSLGNGIWELKREEI 417

  Fly   527 MLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKH 591
            .|::||||||||||:.|||:|..|.||||:|||:||||:|.:||:.|.||.||.||:.||||||.
Human   418 TLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKE 482

  Fly   592 RPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVG 656
            .||||||||:.:|.||||||.|.|.|  ....||:||..|.:||.:||.|.:||||||||||||.
Human   483 YPIYIVTEYISNGCLLNYLRSHGKGL--EPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVD 545

  Fly   657 SENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGK 721
            .:..|||:|||:.||||||||.||.|||||:||:.|||.:|.::||||||||:|:||||:|:.||
Human   546 RDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGK 610

  Fly   722 MPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            .||....|::||.:|.:|..|.:|...:..||.:|..||...||:||.|:.|:..:
Human   611 QPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSI 666

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Btk29ANP_001097121.1 PH_Btk 44..222 CDD:269944 51/176 (29%)
SH3_Tec_like 346..399 CDD:212702 12/69 (17%)
SH2_Tec_family 403..505 CDD:198188 48/112 (43%)
PTKc_Tec_like 521..778 CDD:173637 147/257 (57%)
Pkinase_Tyr 526..777 CDD:285015 146/250 (58%)
BMXNP_001712.1 PH_Btk 7..147 CDD:269944 50/172 (29%)
SH2_Tec_Bmx 289..394 CDD:198262 47/104 (45%)
PTKc_Btk_Bmx 412..667 CDD:173657 147/257 (57%)
CAV1-binding 596..603 4/6 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 316 1.000 Domainoid score I1267
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000006
OrthoInspector 1 1.000 - - otm42091
orthoMCL 1 0.900 - - OOG6_102306
Panther 1 1.100 - - O PTHR24418
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X592
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.910

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