DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and BLK

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	XP_011542126.1	Gene:	BLK / 640	HGNCID:	1057	Length:	531	Species:	Homo sapiens

Alignment Length:	482	Identity:	185/482 - (38%)
Similarity:	271/482 - (56%)	Gaps:	46/482 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 TPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDAL-GNVGYI 392
            ||..|:....::.||   |||||.:.|:...||.:.|..:.:|:..:.: ||..:..: |..||:
Human    48 TPPPPDEHLDEDKHF---VVALYDYTAMNDRDLQMLKGEKLQVLKGTGD-WWLARSLVTGREGYV 108

  Fly   393 PSNYVKPKALLGLERYEWYVGDMSRQRAE-SLLKQGDKEGCFVVRKSST-KGLYTLSLHTKVPQS 455
            |||:|.....|.:||  |:.....|:.|| .||...:|.|.|::|:|.| ||.::||:.....|.
Human   109 PSNFVARVESLEMER--WFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQG 171

  Fly   456 H-VKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVP--PTAGLSHD 517
            . :|||.|:......||:|.:....::..|:.::.....|| |:..:.||.||.|  |.|   .|
Human   172 ELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGL-CQRLTLPCVRPAPQNPWA---QD 232

  Fly   518 KWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLV 582
            :|||....|.|:.:|||||||.|..|.::.::..|:|.:||||||.:.|:.||.||..|||..||
Human   233 EWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLV 297

  Fly   583 QLYGVCSKHRPIYIVTEYMKHGS--------------------------LLNYLRRHEKTLIGNM 621
            :||.|.:| .|||||||||..|.                          ||::|:..|.:.: ::
Human   298 RLYAVVTK-EPIYIVTEYMARGGAPRRAASSERGGRAGLSRRRRVRCGCLLDFLKTDEGSRL-SL 360

  Fly   622 GLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFP 686
            ..|:||..|:::||.|:||.|.|||||.|.|.||......|:||||||| ::|.:||:..|.|||
Human   361 PRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLAR-IIDSEYTAQEGAKFP 424

  Fly   687 IKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKE 751
            |||..||.:::..|:.|:|||::|||:.|:.|.|::||..:.|.||:..::||..:.:|.:|..|
Human   425 IKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPE 489

  Fly   752 IY-DVMKLCWSHGPEERPAFRVLMDQL 777
            :| .|:..||...|||||.|..|...|
Human   490 LYRGVIAECWRSRPEERPTFEFLQSVL 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	19/53 (36%)
		SH2_Tec_family	403..505	CDD:198188	32/104 (31%)
		PTKc_Tec_like	521..778	CDD:173637	120/284 (42%)
		Pkinase_Tyr	526..777	CDD:285015	118/277 (43%)
BLK	XP_011542126.1	SH3_Blk	62..115	CDD:212942	20/56 (36%)
		SH2_Src_Blk	120..219	CDD:198234	30/101 (30%)
		PKc_like	233..522	CDD:304357	122/287 (43%)
		Pkinase_Tyr	241..516	CDD:285015	118/277 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820