Protein Alignment Btk and PTK6

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_005966.1
• Gene: PTK6 / 5753
• HGNCID: 9617
• Length: 451
• Species: Homo sapiens
• Alignment Length: 450
• Identity: 163/450 - (36%)
• Similarity: 244/450 - (54%)
• Gaps: 18/450 - (4%)

  Fly   337 AKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWK--VKDALGNV--GYIPSNYV 397
            ::|.:|.....|.|:.||:....:||......:.|....::.||.  :.:|.|.|  ||:|.||:
Human     3 SRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYL 67

  Fly   398 KPKALLGLERYEWYVGDMSRQRA-ESLLKQGDKEGCFVVRKSSTKGL-YTLSLHTKVPQSHVKHY 460
            ..:..  :|...|:.|.:||..| ..|..:|:..|.|::|.|..... |.||:.   ....|:||
Human    68 AERET--VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVR---DTQAVRHY 127

  Fly   461 HIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSH-DKWEIHPM 524
            .|.:.|....:|:|.....::|:|:||||..|.....|| ::||.:..|..  |.| |.||....
Human   128 KIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRL-AAPCRKHEPEP--LPHWDDWERPRE 189

  Fly   525 ELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIE-EAKVMTKLQHPNLVQLYGVC 588
            |..|..:||||.||.|..|.|:..:..|:|::....:.....:: |.:.|.||:|.:::.||.|.
Human   190 EFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVV 254

  Fly   589 SKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNC 653
            |...|:||:||.|..||||..||..::.:: .:..|||:..||::||.|||..|||||||||||.
Human   255 SVGDPVYIITELMAKGSLLELLRDSDEKVL-PVSELLDIAWQVAEGMCYLESQNYIHRDLAARNI 318

  Fly   654 LVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFT 718
            |||...:.||.||||||.:.:|.|.|. ....|.||..||.|:...:|:|||||::|:|:.|:|:
Human   319 LVGENTLCKVGDFGLARLIKEDVYLSH-DHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFS 382

  Fly   719 CGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLA 778
            .|::||..:.|.|...||..|..:..|..|...::.:|..||...||:||.|:.|.::|:
Human   383 RGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLS 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	17/56 (30%)
		SH2_Tec_family	403..505	CDD:198188	32/103 (31%)
		PTKc_Tec_like	521..778	CDD:173637	104/257 (40%)
PTK6	NP_005966.1	SH3_Brk	12..69	CDD:212781	17/56 (30%)
		SH2_PTK6_Brk	75..174	CDD:198221	32/102 (31%)
		Linker	171..190		6/20 (30%)
		PTKc_Srm_Brk	184..444	CDD:133248	107/260 (41%)