DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and PTK2

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:XP_047277972.1 Gene:PTK2 / 5747 HGNCID:9611 Length:1147 Species:Homo sapiens


Alignment Length:571 Identity:147/571 - (25%)
Similarity:227/571 - (39%) Gaps:185/571 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   362 SLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNY---VKPKALLGLERYEWYVGDMSRQ----- 418
            :|||.:.|||::         || :|...:.|.:.   ||.|.|..|      :....||     
Human   238 ALEKKSNYEVLE---------KD-VGLKRFFPKSLLDSVKAKTLRKL------IQQTFRQFANLN 286

  Fly   419 RAESLLK---------QGDKEGCFVVRKSSTKGLYTLSLHTKV-PQSHVKHYHIKQNARCEYYLS 473
            |.||:||         :.||| ||   |.:....:.:|:...: |:..:.            ||:
Human   287 REESILKFFEILSPVYRFDKE-CF---KCALGSSWIISVELAIGPEEGIS------------YLT 335

  Fly   474 EKHCCET---------------------------------------------------------- 480
            :|.|..|                                                          
Human   336 DKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCR 400

  Fly   481 -----------------------IPDLINYHRHN--------SGGLACRLKSSP---------CD 505
                                   ||.|.|..:..        ||...|:.|...         |.
Human   401 LVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSGVSHCQHKVKKARRFLPLVFCS 465

  Fly   506 RPVPPTAGLSHDK----------------------------WEIHPMELMLMEELGSGQFGVVRR 542
            ...|.|..:|.|:                            :||....:.|...:|.||||.|.:
Human   466 HDPPSTDEISGDETDDYAEIIDEEDTYTMPSKSYGIDEARDYEIQRERIELGRCIGEGQFGDVHQ 530

  Fly   543 GKWRG----SIDTAVKMMKEGTMS--EDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYM 601
            |.:..    ::..|:|..|..|..  .:.|::||..|.:..||::|:|.||.::: |::|:.|..
Human   531 GIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITEN-PVWIIMELC 594

  Fly   602 KHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADF 666
            ..|.|.::|:..:.:|  ::..|:....|:|..:.|||...::|||:||||.||.|.:.||:.||
Human   595 TLGELRSFLQVRKYSL--DLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDF 657

  Fly   667 GLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTE 731
            ||:||:.|..|..:...|.||||..||.:|:.||:|.||||.:||.||||...|..|:..:||.:
Human   658 GLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNND 722

  Fly   732 VVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQ 782
            |:.|::.|..|..|.:|...:|.:|..||::.|..||.|..|..||:.:.:
Human   723 VIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILE 773

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 11/39 (28%)
SH2_Tec_family 403..505 CDD:198188 29/214 (14%)
PTKc_Tec_like 521..778 CDD:173637 97/262 (37%)
PTK2XP_047277972.1 FERM_N_2 86..181 CDD:436229
B41 87..309 CDD:214604 25/87 (29%)
FERM_C_FAK1 305..415 CDD:270011 13/125 (10%)
PTKc_FAK 507..776 CDD:133187 99/270 (37%)
Focal_AT 1011..1140 CDD:460992
Blue background indicates that the domain is not in the aligned region.

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