DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and fynb

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_001025140.1	Gene:	fynb / 574422	ZFINID:	ZDB-GENE-050706-89	Length:	544	Species:	Danio rerio

Alignment Length:	478	Identity:	201/478 - (42%)
Similarity:	287/478 - (60%)	Gaps:	21/478 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 PTLLNGNGTLLDANMP--GGIPT---PGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAE 368
            |...|.:|..:...|.  |||.|   .||..::....   |.|.||||.::|....|||..|..:
Zfish    54 PNYNNFHGAAVPQGMTVFGGISTSTHQGTLRTRGGTG---VTLFVALYDYEARTEDDLSFRKGEK 115

  Fly   369 YEVIDDSQEHWWKVKD-ALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAE-SLLKQGDKEG 431
            :::|:.::..||..:. ..|..||||||||.|  :..::..:||.|.:.|:.|| .||..|:..|
Zfish   116 FQIINSTEGDWWDARSLTTGGTGYIPSNYVAP--VDSIQAEDWYFGKLGRKDAERQLLSTGNPRG 178

  Fly   432 CFVVRKS-STKGLYTLSLH--TKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSG 493
            .|::|:| :|||.::||:.  ..|...|||||.|::.....||::.:...||:..|:.::...:.
Zfish   179 TFLIRESETTKGAFSLSIRDWDDVKGDHVKHYKIRKLDSGGYYITTRAQFETLQQLVQHYTERAA 243

  Fly   494 GLACRLKSSPCDRPVPPTAGLS---HDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKM 555
            ||.||| ..||.:.:|....||   .|.|||....|.|::.||:||||.|..|.|.|:...|:|.
Zfish   244 GLCCRL-VVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT 307

  Fly   556 MKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGN 620
            :|.||||.:.|:|||::|.||:|..|||||.|.|: .|||||||||..||||::|:..|...: .
Zfish   308 LKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVSE-EPIYIVTEYMGKGSLLDFLKDGEGRAL-K 370

  Fly   621 MGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKF 685
            :..|:||..||:.||.|:||.|||||||.:.|.|||...|.|:|||||||.:.|::||:..|.||
Zfish   371 LPNLVDMAAQVAGGMAYIERMNYIHRDLRSANILVGDSLVCKIADFGLARLIEDNEYTARQGAKF 435

  Fly   686 PIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAK 750
            ||||..||...|.:|:.|||||::|:|:.|:.|.|::||..:.|.||:|:|:||..::.|:.|..
Zfish   436 PIKWTAPEAALYGKFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMQCPQDCPS 500

  Fly   751 EIYDVMKLCWSHGPEERPAFRVL 773
            .::::|..||....||||.|..|
Zfish   501 SLHELMVQCWKKDAEERPTFEYL 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	22/53 (42%)
		SH2_Tec_family	403..505	CDD:198188	36/105 (34%)
		PTKc_Tec_like	521..778	CDD:173637	124/253 (49%)
		Pkinase_Tyr	526..777	CDD:285015	123/248 (50%)
fynb	NP_001025140.1	SH3_Fyn_Yrk	92..147	CDD:212939	22/54 (41%)
		SH2_Src_Fyn_isoform_a_like	152..252	CDD:198281	35/100 (35%)
		PKc_like	268..541	CDD:304357	127/258 (49%)
		Pkinase_Tyr	278..527	CDD:285015	123/248 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820