Protein Alignment Btk and tec

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_001108215.2
• Gene: tec / 571588
• ZFINID: ZDB-GENE-030131-7499
• Length: 639
• Species: Danio rerio
• Alignment Length: 736
• Identity: 293/736 - (39%)
• Similarity: 407/736 - (55%)
• Gaps: 136/736 - (18%)

  Fly    47 SMVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVRLVE----EATVSG 107
            :::||:|.|||.:|:|||.|.|.|||...:|::: ..|:|.::|.:.|:.|:.||    ..||..
Zfish    10 TLIKRSQQKKRTSPLNYKERVFVLTKSKLTYYEL-RAEKRFKKGSVDLQRVKCVEIVKNNTTVIP 73

  Fly   108 EGGDPFAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSEKER 172
                  ..:.|||||.|                                 ...|||:.|.|.:.|
Zfish    74 ------CQNKYPFQVVY---------------------------------DSSTLYIFAPSNESR 99

  Fly   173 SEWIRAIRQVCEDSNTPK-SYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREANNNPSNGSSP 236
            |.|::.|::  |..|.|. :.:||...|...:|.||..:.:...||.....:.:.:..|......
Zfish   100 SVWVQNIKE--EIRNNPLIADKYHSQFWQEGEWLCCGQVDKLAPGCEGYNLFGDVSRKPLPPVPE 162

  Fly   237 AQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSS 301
            .||.                                                 |||.....|
Zfish   163 DQNI-------------------------------------------------SCTGRRPPP--- 175

  Fly   302 LTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKN 366
                                      |.||  .:|.::.....::|:|||.|:.:|..||:|:..
Zfish   176 --------------------------PPPG--ETKQEEEEPEEEVVIALYDFEGLEPHDLTLKTG 212

  Fly   367 AEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEG 431
            .||.:::..:.:|:|.::..|..||||||||..||...||::.|:..:::|.:||.||::..|||
Zfish   213 EEYVILEKCEVNWYKARNKEGKQGYIPSNYVTEKASDKLEQFIWFSKNVNRNKAEELLRKEGKEG 277

  Fly   432 CFVVRKSSTKGLYTLSLHTKVPQ---SHVKHYHIKQ--NARCEYYLSEKHCCETIPDLINYHRHN 491
            .|:||.||..|.||:||:||...   :.::||.||:  .:..::||:||:...:||:||.||:||
Zfish   278 GFMVRLSSNTGTYTVSLYTKSTSDGAAAIRHYQIKEIHASPKQFYLAEKYIFTSIPELIEYHKHN 342

  Fly   492 SGGLACRLKSSPCD--RPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVK 554
            :.||..||:.:..|  |..|.|||.|:|||||:|.||..|:|||||||||||.||||.....|:|
Zfish   343 AAGLVSRLRHAVGDQKREAPTTAGFSYDKWEINPSELTFMKELGSGQFGVVRLGKWRAQHKVAIK 407

  Fly   555 MMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIG 619
            .::||.|||||||||||:|..|.|.|||||||||::.:|||:|||:|:.|.|||:||:...||..
Zfish   408 TIREGAMSEDDFIEEAKIMMNLSHRNLVQLYGVCTQQKPIYLVTEFMELGCLLNFLRQRRGTLAA 472

  Fly   620 NMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTK 684
            ..  ||.:|..:|:||.:||.:.:||||||||||||.|..||||:|||:.||||||||.||.|||
Zfish   473 QD--LLGICHDISQGMQHLEENRFIHRDLAARNCLVNSSMVVKVSDFGMTRYVLDDQYWSSSGTK 535

  Fly   685 FPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCA 749
            ||:||:||||.|:.|:|||||||::||||||:||.||||:...:|.|||..|.:|..|.:||..|
Zfish   536 FPVKWSPPEVFNFCRYSSKSDVWSFGVLMWEVFTEGKMPFEHSQNHEVVLMVTQGHRLYRPKKAA 600

  Fly   750 KEIYDVMKLCWSHGPEERPAF 770
            ..||::||:||...|:|||.|
Zfish   601 PHIYNIMKMCWMEKPDERPTF 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	51/179 (28%)
		SH3_Tec_like	346..399	CDD:212702	22/52 (42%)
		SH2_Tec_family	403..505	CDD:198188	43/106 (41%)
		PTKc_Tec_like	521..778	CDD:173637	153/250 (61%)
tec	NP_001108215.2	PH_Btk	7..148	CDD:269944	51/179 (28%)
		SH3_Tec	192..246	CDD:212838	22/53 (42%)
		SH2_Tec_Itk	249..356	CDD:198259	43/106 (41%)
		Protein Kinases, catalytic domain	374..629	CDD:473864	153/250 (61%)