DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Btk29A and tec

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_001108215.1	Gene:	tec / 571588	ZFINID:	ZDB-GENE-030131-7499	Length:	622	Species:	Danio rerio

Alignment Length:	712	Identity:	280/712 - (39%)
Similarity:	391/712 - (54%)	Gaps:	136/712 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 SMVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVRLVE----EATVSG 107
            :::||:|.|||.:|:|||.|.|.|||...:|::: ..|:|.::|.:.|:.|:.||    ..||..
Zfish    10 TLIKRSQQKKRTSPLNYKERVFVLTKSKLTYYEL-RAEKRFKKGSVDLQRVKCVEIVKNNTTVIP 73

  Fly   108 EGGDPFAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSEKER 172
                  ..:.|||||.|                                 ...|||:.|.|.:.|
Zfish    74 ------CQNKYPFQVVY---------------------------------DSSTLYIFAPSNESR 99

  Fly   173 SEWIRAIRQVCEDSNTPK-SYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREANNNPSNGSSP 236
            |.|::.|::  |..|.|. :.:||...|...:|.||..:.:...||.....:.:.:..|......
Zfish   100 SVWVQNIKE--EIRNNPLIADKYHSQFWQEGEWLCCGQVDKLAPGCEGYNLFGDVSRKPLPPVPE 162

  Fly   237 AQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSS 301
            .||.                                                 |||.....|
Zfish   163 DQNI-------------------------------------------------SCTGRRPPP--- 175

  Fly   302 LTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKN 366
                                      |.||  .:|.::.....::|:|||.|:.:|..||:|:..
Zfish   176 --------------------------PPPG--ETKQEEEEPEEEVVIALYDFEGLEPHDLTLKTG 212

  Fly   367 AEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEG 431
            .||.:::..:.:|:|.::..|..||||||||..||...||::.|:..:::|.:||.||::..|||
Zfish   213 EEYVILEKCEVNWYKARNKEGKQGYIPSNYVTEKASDKLEQFIWFSKNVNRNKAEELLRKEGKEG 277

  Fly   432 CFVVRKSSTKGLYTLSLHTKVPQ---SHVKHYHIKQ--NARCEYYLSEKHCCETIPDLINYHRHN 491
            .|:||.||..|.||:||:||...   :.::||.||:  .:..::||:||:...:||:||.||:||
Zfish   278 GFMVRLSSNTGTYTVSLYTKSTSDGAAAIRHYQIKEIHASPKQFYLAEKYIFTSIPELIEYHKHN 342

  Fly   492 SGGLACRLKSSPCD--RPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVK 554
            :.||..||:.:..|  |..|.|||.|:|||||:|.||..|:|||||||||||.||||.....|:|
Zfish   343 AAGLVSRLRHAVGDQKREAPTTAGFSYDKWEINPSELTFMKELGSGQFGVVRLGKWRAQHKVAIK 407

  Fly   555 MMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIG 619
            .::||.|||||||||||:|..|.|.|||||||||::.:|||:|||:|:.|.|||:||:...||..
Zfish   408 TIREGAMSEDDFIEEAKIMMNLSHRNLVQLYGVCTQQKPIYLVTEFMELGCLLNFLRQRRGTLAA 472

  Fly   620 NMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTK 684
            ..  ||.:|..:|:||.:||.:.:||||||||||||.:..||||:|||:.||||||||.||.|||
Zfish   473 QD--LLGICHDISQGMQHLEENRFIHRDLAARNCLVNTSMVVKVSDFGMTRYVLDDQYWSSSGTK 535

  Fly   685 FPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPK 746
            ||:||:||||.|:.|:|||||||::||||||:||.||||:...:|.|||..|.:|..|.:||
Zfish   536 FPVKWSPPEVFNFCRYSSKSDVWSFGVLMWEVFTEGKMPFEHSQNHEVVLMVTQGHRLYRPK 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944	51/179 (28%)
		SH3_Tec_like	346..399	CDD:212702	22/52 (42%)
		SH2_Tec_family	403..505	CDD:198188	43/106 (41%)
		PTKc_Tec_like	521..778	CDD:173637	140/226 (62%)
		Pkinase_Tyr	526..777	CDD:285015	137/221 (62%)
tec	NP_001108215.1	PH	6..111	CDD:278594	41/142 (29%)
		PH_Btk	7..148	CDD:269944	51/179 (28%)
		SH3_Tec	192..246	CDD:212838	22/53 (42%)
		SH2_Tec_Itk	249..356	CDD:198259	43/106 (41%)
		PKc_like	374..602	CDD:304357	140/226 (62%)
		Pkinase_Tyr	379..602	CDD:285015	137/221 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9078
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1302
Inparanoid	1	1.050	540	1.000	Inparanoid score	I1147
OMA	1	1.010	-	-		QHG52659
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm24880
orthoMCL	1	0.900	-	-		OOG6_102306
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X592
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.970