DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and blk

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:XP_017208000.1 Gene:blk / 567764 ZFINID:ZDB-GENE-040724-106 Length:501 Species:Danio rerio


Alignment Length:472 Identity:187/472 - (39%)
Similarity:277/472 - (58%) Gaps:22/472 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly   320 DANMPGGIPTPGTPNSKA---------KDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDS 375
            |.|.|.|.....:.|||.         ::|:....:|:|.|.|:.....||..:|.....:|.::
Zfish    23 DQNHPKGHEHYNSTNSKTSHASRDHKKQNNNQDEDVVIAQYDFQPASENDLQFKKGDRLRIIKEN 87

  Fly   376 QEHWWKVKDAL-GNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAES-LLKQGDKEGCFVVRKS 438
            .| ||..|..: |..|:|||.||.....|.:||  |:..||:|:..|. ||..|:|.|.|:||:|
Zfish    88 GE-WWLAKSLVTGYEGFIPSTYVARAQTLQVER--WFFKDMNRRDTERLLLAPGNKPGSFLVRES 149

  Fly   439 -STKGLYTLSLHTKVPQSH--VKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLK 500
             :|||.::||:....|:..  ||||.|:......||:|......::.:|:.|:...:.|| |:..
Zfish   150 ETTKGAFSLSIRDSTPEQGDVVKHYKIRALDNGGYYISPSTSFSSLQELVKYYSRTADGL-CQRL 213

  Fly   501 SSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDD 565
            .:|| :...|....:.|:|||....|.|:::||:||||.|..|.::.:...|:|.:|||||..:.
Zfish   214 GNPC-KSTAPQRPWAQDEWEIPRETLKLVKKLGAGQFGEVWMGFYKNNQKVAIKTLKEGTMEPEA 277

  Fly   566 FIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQ 630
            |::||.:|.:|||..||:|:.|.:: .|||||||||.:||||::|:..:...: .:..|:||..|
Zfish   278 FLQEANLMKQLQHERLVKLHAVVTR-EPIYIVTEYMANGSLLDFLKTDDGHKL-KLSKLIDMTAQ 340

  Fly   631 VSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVL 695
            :::||.|:||.|||||||.|.|.||......|:||||||| :::.:||:..|.||||||..||.:
Zfish   341 IAEGMAYIERKNYIHRDLRAANILVSETLHCKIADFGLAR-IIETEYTAQEGAKFPIKWTAPEAI 404

  Fly   696 NYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCW 760
            ||..|:.|||||::|:|:.||.|.|::||..:.|.||:..:.|...:..|.:|..|:||:|..||
Zfish   405 NYGTFTIKSDVWSFGILLTEIVTYGRVPYPGMTNPEVIRNLDRNYRMPCPDACPGELYDIMTKCW 469

  Fly   761 SHGPEERPAFRVLMDQL 777
            ...||:||.|..|.|.|
Zfish   470 MEKPEDRPTFEYLQDTL 486

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 19/53 (36%)
SH2_Tec_family 403..505 CDD:198188 37/105 (35%)
PTKc_Tec_like 521..778 CDD:173637 118/257 (46%)
blkXP_017208000.1 SH3_Blk 58..111 CDD:212942 19/53 (36%)
SH2_Src_family 116..216 CDD:199827 35/102 (34%)
PTKc_Lck_Blk 230..492 CDD:270652 120/260 (46%)
Blue background indicates that the domain is not in the aligned region.

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