Protein Alignment Btk and map3k10

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_689424.4
• Gene: map3k10 / 560932
• ZFINID: ZDB-GENE-050419-112
• Length: 1062
• Species: Danio rerio
• Alignment Length: 548
• Identity: 136/548 - (24%)
• Similarity: 218/548 - (39%)
• Gaps: 170/548 - (31%)

  Fly   280 GLGGGGGG----------GGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGT-- 332
            |:|.||||          ||||  ..|.|..:......:|.|::.|.:...:.:|..:.:|.:
Zfish     9 GVGAGGGGSAAPLPCISSGGSC--GHLVPPDTQANTNSTPFLISINSSRNSSTIPSSVGSPDSHL 71

  Fly   333 PNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVID-DSQ----EHWW--KVKDALGNVG 390
            |:.....|:::    .|::.::|....:|:|.:....||:. ||:    |.||  |::|   .||
Zfish    72 PHHHESSNTYW----TAVFDYEATADEELTLRRGDLLEVLSKDSKVSGDEGWWTGKIQD---KVG 129

  Fly   391 YIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQS 455
            ..|.|||                                    ..|.||...|
Zfish   130 IFPCNYV------------------------------------TQRDSSYPAL------------ 146

  Fly   456 HVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDK-W 519
                                                                 ||.|.:..|. .
Zfish   147 -----------------------------------------------------PPEALVGGDSPL 158

  Fly   520 EIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEG-----TMSEDDFIEEAKVMTKLQHP 579
            ||..:||.|.|.:|:|.||.|.:|.||.. :.|||..::.     :.:.::..:||::...|:|.
Zfish   159 EIDFLELRLEEVIGAGGFGKVYKGVWRAE-EVAVKAARQDPDEDISATAENVRQEARLFWMLRHR 222

  Fly   580 NLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNM---GLLLDMCIQVSKGMTYLERH 641
            |::.|.|||.:...:.:|.||.:.|:|       .:.|.|..   .:|::..:|::.||.||...
Zfish   223 NIIALRGVCLREPNLCLVMEYARGGAL-------NRALAGKKVPPRVLVNWAVQIATGMDYLHNQ 280

  Fly   642 NY---IHRDLAARNCLV--------GSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVL 695
            .:   |||||.:.|.|:        .|...:|:.||||||........|:.||   ..|..|||:
Zfish   281 TFVPIIHRDLKSSNILILEPVERDDLSGKTLKITDFGLAREWHRTTKMSAAGT---YAWMAPEVI 342

  Fly   696 NYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEK-----PKSCAKEIYDV 755
            ..:.||..||||::|||:||:.| |::||..:....|.    .|:.:.|     |.:|.:....:
Zfish   343 KLSLFSKSSDVWSFGVLLWELLT-GEVPYREIDALAVA----YGVAMNKLTLPIPSTCPEAFAQL 402

  Fly   756 MKLCWSHGPEERPAFRVLMDQLALVAQT 783
            :..||...|..||||..::.:|..:.|:
Zfish   403 LGECWCPNPRGRPAFGSILKRLEDIEQS 430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	19/59 (32%)
		SH2_Tec_family	403..505	CDD:198188	4/101 (4%)
		PTKc_Tec_like	521..778	CDD:173637	87/280 (31%)
map3k10	XP_689424.4	SH3_MLK1-3	81..138	CDD:212992	19/99 (19%)
		STKc_MLK2	170..427	CDD:271050	83/272 (31%)