Protein Alignment Btk and tnk2b

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_021336227.1
• Gene: tnk2b / 559119
• ZFINID: ZDB-GENE-110411-165
• Length: 1118
• Species: Danio rerio
• Alignment Length: 291
• Identity: 117/291 - (40%)
• Similarity: 166/291 - (57%)
• Gaps: 25/291 - (8%)

  Fly   506 RPVPPTAGLSHDKWE-----IHPMELMLMEELGSGQFGVVRRGKW---RGSI-DTAVKMMKEGTM 561
            |.:.||..|...:.:     |...:|.|.|:||.|.||||:||:|   .|.: :.|||.:|...:
Zfish   124 RKLSPTPPLVDGQQQALTCLISEKDLALFEKLGDGSFGVVKRGEWFTPNGKVLNVAVKCLKTDVL 188

  Fly   562 SE----DDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMG 622
            ::    ||||.|...|..|.|.||::||||...| |:.:|||....||:|:.||   ||| |:.
Zfish   189 NQPDALDDFIREVNAMHSLDHQNLIRLYGVVLTH-PMKMVTELAPLGSMLDRLR---KTL-GHF- 247

  Fly   623 LLLDMC---IQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYV--LDDQYTSSGG 682
            |:..:|   ||:|.||.|||...:|||||||||.|:.|...||:.||||.|.:  .||.|.....
Zfish   248 LISTLCQYTIQISNGMGYLESKRFIHRDLAARNILLASSEQVKIGDFGLMRALPKNDDHYVMQEH 312

  Fly   683 TKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQR-GIILEKPK 746
            .|.|..|..||.|....||..:|.|.:||.:||:||.|:.|:..|..::::.::.: |..|.||:
Zfish   313 RKVPFAWCAPESLKTRTFSHATDTWMFGVTLWEMFTYGQEPWLGLNGSQILHKIDKEGERLPKPE 377

  Fly   747 SCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            .|.:::|:||..||:..|::||.|..|.:.|
Zfish   378 DCPQDLYNVMMQCWAQKPDDRPTFVALREFL 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188
		PTKc_Tec_like	521..778	CDD:173637	113/271 (42%)
tnk2b	XP_021336227.1	SAM_TNK-like	32..93	CDD:188938
		PTKc_Ack_like	153..410	CDD:270636	110/262 (42%)
		SH3	416..464	CDD:214620
		GTPase_binding	472..537	CDD:430374
		PHA03247	<609..750	CDD:223021
		Inhibitor_Mig-6	851..927	CDD:463294
		UBA_ACK1	1039..1082	CDD:270460
		UBA_TNK1	1069..1108	CDD:270513