Protein Alignment Btk and ptk2ba

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_005158634.1
• Gene: ptk2ba / 557258
• ZFINID: ZDB-GENE-080207-1
• Length: 933
• Species: Danio rerio
• Alignment Length: 298
• Identity: 110/298 - (36%)
• Similarity: 177/298 - (59%)
• Gaps: 14/298 - (4%)

  Fly   486 NYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGS-- 548
            |...|..|      |:|.....:|....|:..|:.|...:::|...||.|.||.|..|.::..
Zfish   366 NTTSHKEG------KNSDIYAEIPEEKPLAACKFSISRNDIVLGRILGEGFFGEVHDGIYKSKSG 424

  Fly   549 --IDTAVKMMKEGTMS-EDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYL 610
              ::.|||..|:.:.. ::.|:.||.:|.||.||::|:|.|:..:. |::||.|....|.|.|||
Zfish   425 ERVNVAVKTCKDCSADVKEKFMSEALIMKKLDHPHIVRLIGIIEED-PVWIVMELYPFGELENYL 488

  Fly   611 RRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDD 675
            :.::..|. |:.|:| ..:|:||.:.|||..|.:|||:|.||.||...:.||:.||||:||:.::
Zfish   489 KDNQNKLT-NVTLIL-YSLQISKALAYLEGVNMVHRDIAVRNVLVAKVDCVKLGDFGLSRYIEEE 551

  Fly   676 QYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGI 740
            :|..:..|:.||||..||.:|:.||:|.||||.:.|.||||.:.|:.|:..|:|.:|:.::::|:
Zfish   552 EYYKASVTRLPIKWMAPESINFRRFTSASDVWMFAVCMWEIMSGGQQPFFWLENKDVINQLEQGM 616

  Fly   741 ILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLA 778
            .|.||:.|...:|.:|..|||:.|.:||:|..|:.:|:
Zfish   617 RLPKPERCPPTLYSLMTRCWSYSPRDRPSFTELVCKLS 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188	5/18 (28%)
		PTKc_Tec_like	521..778	CDD:173637	101/261 (39%)
ptk2ba	XP_005158634.1	FERM_N_2	20..118	CDD:436229
		B41	33..246	CDD:214604
		FERM_C_FAK1	242..351	CDD:270011
		Protein Kinases, catalytic domain	393..657	CDD:473864	102/265 (38%)
		Focal_AT	796..925	CDD:460992