DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Btk29A and csk

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_001071067.1	Gene:	csk / 556454	ZFINID:	ZDB-GENE-061103-493	Length:	450	Species:	Danio rerio

Alignment Length:	439	Identity:	167/439 - (38%)
Similarity:	254/439 - (57%)	Gaps:	22/439 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 VALYPFKAIEGGDLSLEKNAEYEVIDDSQE-HWWKVKDALGNVGYIPSNYVKP----KALLGLER 407
            ||.|.|......||.:.|.....::..::: :|::.|::.|..|.||:|||:.    |:...|..
Zfish    15 VARYNFPGTADQDLPMCKGDVLTIVGVTKDPNWYRAKNSAGREGTIPANYVQKREGVKSASKLSL 79

  Fly   408 YEWYVGDMSRQRAESLLKQGDKEGCFVVRKSST-KGLYTLSLHTKVPQSHVKHYH-IKQNARCEY 470
            ..|:.|.::|::||.|| ...:.|.|:||:|:. .|.|||.:..   ...|:||. |..|.:..
Zfish    80 MPWFHGKITREQAERLL-YPPETGLFLVRESTNYPGDYTLCVSC---DGKVEHYRIIYHNGKLS- 139

  Fly   471 YLSEKHCCETIPDLINYHRHNSGGLACRL-KSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGS 534
             :.|:...|.:..|:.::..::.||..|| |....:..|......|...|.::..||.|::.:|.
Zfish   140 -IDEEEYFENLMQLMEHYTKDADGLCTRLIKPKIMEGTVAAQDEFSRSGWALNRKELKLIQTIGK 203

  Fly   535 GQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHR-PIYIVT 598
            |:||.|..|.:||. ..|||.:|....:: .|:.||.|||:|:|.|||||.||..:.: .:||||
Zfish   204 GEFGDVMVGDYRGK-KVAVKCIKHDATAQ-AFVAEASVMTQLRHNNLVQLLGVIVEEKGSLYIVT 266

  Fly   599 EYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKV 663
            |||..|||::|||...:|:||. ..|::..:.|.|.|.|||.:|::||||||||.||..:|:.||
Zfish   267 EYMAKGSLVDYLRSRGRTVIGG-DRLINFSMDVCKAMEYLEANNFVHRDLAARNVLVSEDNIAKV 330

  Fly   664 ADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLK 728
            :||||.:.....|.|:    |.|:||..||.|...:||:|||||:||:|:|||::.|::||.|:.
Zfish   331 SDFGLTKEASSTQDTA----KLPVKWTSPEALREKKFSTKSDVWSYGILLWEIYSFGRVPYPRIP 391

  Fly   729 NTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            ..|||.||::|..::.|..|...:||:||.||:.....||:||.|.::|
Zfish   392 LKEVVPRVEKGYKMDSPDGCPPVVYDIMKQCWTLDAVVRPSFRDLREKL 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	16/51 (31%)
		SH2_Tec_family	403..505	CDD:198188	30/104 (29%)
		PTKc_Tec_like	521..778	CDD:173637	117/258 (45%)
		Pkinase_Tyr	526..777	CDD:285015	115/251 (46%)
csk	NP_001071067.1	SH3_CSK	11..67	CDD:212703	16/51 (31%)
		SH2_csk_like	78..175	CDD:198190	29/102 (28%)
		PTKc_Csk	188..443	CDD:133213	118/260 (45%)
		STYKc	195..440	CDD:214568	115/251 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810