Protein Alignment Btk and grap2a

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_001017756.1
• Gene: grap2a / 550452
• ZFINID: ZDB-GENE-050417-275
• Length: 284
• Species: Danio rerio
• Alignment Length: 320
• Identity: 76/320 - (23%)
• Similarity: 119/320 - (37%)
• Gaps: 98/320 - (30%)

  Fly   351 YPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERY--EWYVG 413
            |.|......:||..|....::: .||:.|:|. :..|:.||:|.|||        :|.  .|:..
Zfish     7 YDFSGTAEDELSFRKGDTLKIL-GSQDDWFKA-ELHGHEGYVPKNYV--------DRQIPSWFKE 61

  Fly   414 DMSRQRAESLLKQGDKEGCFVVRKS-STKGLYTLSLHTKVPQSH---VKHYHIKQNARCEYYL-S 473
            ..||..||..| ...:.|.|::|.| |:.|.:::|:.      |   |:|:.:.::....||| :
Zfish    62 SASRGSAEETL-MSREVGAFLIRGSQSSPGDFSISVR------HDYDVQHFKVMKDKSGHYYLWT 119

  Fly   474 EKHCCETIPDLINYHRHNS------------GGLACR----LKSSPCDRPVPPTAGLSHDKWEIH 522
            ||.  .::..|:::::..|            .|...|    :||.|..|| ||..|
Zfish   120 EKF--TSLNKLVDFYKTTSISKQKEIFLRDGSGDEPRAPPPIKSQPEVRP-PPGGG--------- 172

  Fly   523 PMELMLMEELGSGQFGVVRR----------GKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQ 577
                     .||.|.....|          || |||::.     |..|:........|...|...
Zfish   173 ---------YGSPQTSSQNRSTTDPTHNQKGK-RGSVEE-----KSNTLGHQGKNSPAPRRTSET 222

  Fly   578 HP---NLVQLYGVCSKHRPIYIVTEY------MKHGSLLNYLRRHEKT-----LIGNMGL 623
            .|   :.:|:       |.||..|..      ...|.::..|.|.:.:     |.|..||
Zfish   223 APAPRSTIQV-------RAIYDFTAEEDDELGFNSGDIIEVLDRSDASWWKGRLRGRSGL 275

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	16/47 (34%)
		SH2_Tec_family	403..505	CDD:198188	29/124 (23%)
		PTKc_Tec_like	521..778	CDD:173637	26/127 (20%)
grap2a	NP_001017756.1	SH3_GRAP2_N	2..53	CDD:212880	16/55 (29%)
		SH2_Grb2_like	54..147	CDD:199828	23/101 (23%)
		SH3_GRAP2_C	231..283	CDD:212883	12/52 (23%)