DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and lyn

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	XP_012820235.2	Gene:	lyn / 549989	XenbaseID:	XB-GENE-1015126	Length:	508	Species:	Xenopus tropicalis

Alignment Length:	478	Identity:	196/478 - (41%)
Similarity:	282/478 - (58%)	Gaps:	34/478 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 QSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEV 371
            ::|:||.|...|.:....|.|                   |:||||::.|...||:.:|..:.:|
Frog    43 RTPSLLPGQKILQEIEEQGNI-------------------VIALYPYQGIHQDDLTFKKGEKLKV 88

  Fly   372 IDDSQEHWWKVKD-ALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAE-SLLKQGDKEGCFV 434
            |::..| |||.|. :....|:||||||  ..:..||..||:..|::|:.|| .||..|:..|.|:
Frog    89 IEEHGE-WWKAKSLSTKKEGFIPSNYV--ARVNTLETEEWFFKDITRKDAERQLLAPGNNPGAFL 150

  Fly   435 VRKSST-KGLYTLSLHTKVPQSH--VKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLA 496
            :|:|.| ||.|:||:....|::.  :|||.|:......||:|.:....:|.|:|.:::..:.||
Frog   151 IRESETSKGSYSLSIRDYDPKTGDVIKHYKIRTLDNGGYYISPRITFTSICDMIQHYQKQADGL- 214

  Fly   497 CRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTM 561
            ||....||..| .|......|.|||....:.|:::||:||||.|..|.:..|...|||.:|.|||
Frog   215 CRKLDKPCYSP-KPQKPWDKDAWEIPRESIKLVKKLGAGQFGEVWMGFYNNSTKVAVKTLKPGTM 278

  Fly   562 SEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHE--KTLIGNMGLL 624
            |...|:|||.:|..|||..||:||.|.||..||||:||:|..||||::|:..|  |.::..   |
Frog   279 SVQAFMEEANLMKSLQHDKLVRLYAVVSKEEPIYIITEFMAKGSLLDFLKSDEGAKVILPK---L 340

  Fly   625 LDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKW 689
            :|...|:::||.|:|:.|||||||.|.|.||....:.|:|||||||.:.|::||:..|.||||||
Frog   341 IDFSAQIAEGMAYIEKKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKW 405

  Fly   690 APPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYD 754
            ..||.:|:..|:.|||||::|||::||.|.||:||..:.|::|:..:|||..:.:.::|..|:||
Frog   406 TAPEAINFGSFTIKSDVWSFGVLLYEIITTGKIPYPGMSNSDVMTALQRGYRMPRMENCPVELYD 470

  Fly   755 VMKLCWSHGPEERPAFRVLMDQL 777
            :||.||....||||.|..|...|
Frog   471 IMKECWKEKAEERPTFDYLQSVL 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	23/53 (43%)
		SH2_Tec_family	403..505	CDD:198188	37/105 (35%)
		PTKc_Tec_like	521..778	CDD:173637	123/259 (47%)
		Pkinase_Tyr	526..777	CDD:285015	121/252 (48%)
lyn	XP_012820235.2	SH3_Lyn	63..118	CDD:212937	24/76 (32%)
		SH2_Src_Lyn	121..221	CDD:198227	35/100 (35%)
		PTKc_Lyn	235..506	CDD:270657	125/262 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010