DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Btk29A and hck

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_001015722.1	Gene:	hck / 548439	XenbaseID:	XB-GENE-6048191	Length:	498	Species:	Xenopus tropicalis

Alignment Length:	512	Identity:	190/512 - (37%)
Similarity:	281/512 - (54%)	Gaps:	47/512 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 GGGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSK-A 337
            |.|.|||           .|.|.:||:.   :.:.||             ...:.|....:|| .
Frog    11 GSGKSLG-----------PPESTEPQAH---YVKDPT-------------STAVMTKVERSSKHP 48

  Fly   338 KDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKAL 402
            |:......:::|||.:..:..|||:..|.....:..:|.|.|.....:....|::|||||  ..:
Frog    49 KEEGQEEVVLLALYDYDGVHPGDLTFRKGDHLLLKKESGEWWEAYLISTREEGFVPSNYV--ARV 111

  Fly   403 LGLERYEWYVGDMSRQRAE-SLLKQGDKEGCFVVRKS-STKGLYTLSLHTKVPQSHVKHYHIKQN 465
            ..||..|||..||.|:.|| .||...:..|.|::|.| :|||.::||:...  ...|:||.|:.:
Frog   112 DSLESKEWYFKDMGRKEAERQLLSPLNTCGAFMIRDSETTKGSFSLSVRDS--GDTVRHYKIRTH 174

  Fly   466 ARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCD--RPVPPTAGLSHDKWEIHPMELML 528
            ....:::|.:....::|:|:::::....|| |:..:.||.  ||..|   ...|.|||....|.|
Frog   175 EDGGFFISTRITFPSLPELVSHYQGKMSGL-CQCLTVPCQTLRPEKP---WEKDAWEIPRESLSL 235

  Fly   529 MEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRP 593
            .::||:||||.|....:.|..:.|||.||.|:||...|:|||.:|..|||..||:|:.|.::..|
Frog   236 QKKLGTGQFGDVWLATYNGHTEVAVKTMKAGSMSPAAFLEEANLMKSLQHERLVRLHAVVTQGEP 300

  Fly   594 IYIVTEYMKHGSLLNYLRRHEKTLIGN---MGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLV 655
            ||||||||..||||::|:..|    |:   :..|:|.|.|:::||.::|:.|||||||.|.||||
Frog   301 IYIVTEYMHKGSLLDFLKSPE----GSRQPVTQLIDFCAQIAEGMWFIEQRNYIHRDLRAANCLV 361

  Fly   656 GSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCG 720
            ....:.|:|||||||.:.|.:||:..|:||||||..||..||..|:.|||:|::|||:.||.|.|
Frog   362 SETLLCKIADFGLARVIEDSEYTAREGSKFPIKWTSPEAANYGSFTIKSDIWSFGVLLSEIMTYG 426

  Fly   721 KMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            :.||..:.|:||:..::||..:..|.:|..|:|.:|..||...|.:||.|..|.:.|
Frog   427 RSPYPGMSNSEVMAALERGYRMPCPGTCPTELYGIMLQCWQQDPHKRPTFEYLQNIL 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	16/52 (31%)
		SH2_Tec_family	403..505	CDD:198188	32/103 (31%)
		PTKc_Tec_like	521..778	CDD:173637	120/260 (46%)
		Pkinase_Tyr	526..777	CDD:285015	118/253 (47%)
hck	NP_001015722.1	SH3	57..112	CDD:388381	16/56 (29%)
		SH2_Src_family	115..211	CDD:199827	30/98 (31%)
		PTKc_Src_like	237..484	CDD:270630	117/251 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010