Protein Alignment Btk and Tyk2

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_001192241.1
• Gene: Tyk2 / 54721
• MGIID: 1929470
• Length: 1207
• Species: Mus musculus
• Alignment Length: 903
• Identity: 211/903 - (23%)
• Similarity: 312/903 - (34%)
• Gaps: 247/903 - (27%)

  Fly    44 KSGSMVKRAQNKKRFTPVNYKHRWFELTKRTFSYF----DVENVERRRERGRIHLKGVRLVEEAT 104
            :||...|..:..:..|....:..|        :||    |:.:|..:..|..|||:..:.:....
Mouse   373 RSGKKPKAPKAGEHLTESPQEPPW--------TYFCDFQDISHVVLKERRVHIHLQDNKCLLLCL 429

  Fly   105 VSGEGGDPFAP--DGYPFQVGYCEISASANSHQL-------------ENGNGGGSGVGIEGQQSG 154
            .|......|..  ||| |::      .:.:||.|             :||..|..   ::.....
Mouse   430 CSQAEALSFVALVDGY-FRL------TADSSHYLCHEVAPPRLVTSIQNGIHGPL---MDPFVQA 484

  Fly   155 RAVPQYTLYVIANSEKERSEWIRAIRQVCED----SNTPKSYR-------YHPGL-----WSGKK 203
            :..|:..||:|   :...|...|.|..|...    ||.|:..|       ..||.     | |:.
Mouse   485 KLWPEDGLYLI---QWSTSHLHRLILTVAHRNPAFSNGPRGLRLRKFPITQQPGAFVLDGW-GRS 545

  Fly   204 WSCCKGLSRTTFGCRAAA--------HW-----REANNNPSNGSSPAQNSTRSISPNSSTTNSQF 255
            ::....|.....||...|        |.     ||.:|......|.|.....::|..|      |
Mouse   546 FASLGDLRLALQGCSLRAGDDCFPLHHCCLPRPREISNLVIMRGSRAHTRPLNLSQLS------F 604

  Fly   256 SLQHNSSGSLGGGVGGGLGGG---GSLGLGGGGGG--GGSCTPTSLQPQSSLTTFKQSPTLLNGN 315
            ...|....:....:|.|....   |.|.:||...|  ...|.|.
Mouse   605 HRVHQDEITQLSHLGQGTRTNVYEGLLRVGGPDEGKVDNGCPPE--------------------- 648

  Fly   316 GTLLDANMPGGIPTPGTPNS---KAKDNSHFVKLVVALYPFKAI--EGGDLSLE-------KNAE 368
                    |||  |.|....   |..|.||. .:.:|.|...::  :...:.|.       :.:|
Mouse   649 --------PGG--TSGQQLRVVLKVLDPSHH-DIALAFYETASLMSQVSHMHLAFLHGVCVRGSE 702

  Fly   369 YEVIDDSQEH-----W-----------WK--VKDALGNVGYIPSNYVKPK--------------A 401
            ..::.:..||     |           ||  |...|.:.    .:|::.|              |
Mouse   703 NIIVTEFVEHGPLDVWLRRQRGQVPMTWKMVVAQQLASA----LSYLEDKNLVHGNVCGRNILLA 763

  Fly   402 LLGL--------------------------ERYEWYVGDMSRQRAESLLKQGDKEG--------C 432
            .|||                          ||..|...:.......||....|..|        |
Mouse   764 RLGLEEGTNPFIKLSDPGVGQGALSREERVERIPWTAPECLSGGTSSLGTATDMWGFGATLLEIC 828

  Fly   433 F------VVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETI-PDLINYHRH 490
            |      ..|..|.|..:....| ::|:...............|..:::....|| .||......
Mouse   829 FDGEAPLQGRGPSEKERFYTKKH-QLPEPSSPELATLTRQCLTYEPAQRPSFRTILRDLTRLQPQ 892

  Fly   491 NSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSID----- 550
            |..|.:.....||...|.           ..|...|..:.:||.|.||.|....:..:.|
Mouse   893 NLVGTSAVNSDSPASDPT-----------VFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEM 946

  Fly   551 TAVKMMKE--GTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSK--HRPIYIVTEYMKHGSLLNYLR 611
            .|||.:||  |......:..|.:::..|.|.::|:..|.|..  .:.:.:|.||:..|||.:||.
Mouse   947 VAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLP 1011

  Fly   612 RHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLD-- 674
            ||   .:|...||| ...|:.:||.||...:||||||||||.|:.::.:||:.|||||:.|.:
Mouse  1012 RH---CVGLAQLLL-FAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGH 1072

  Fly   675 DQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFT-CGKMPYGRLKNTEVV----- 733
            :.|........|:.|..||.|...:|...||||::||.::|:.| |.......:|.||::
Mouse  1073 EYYRVREDGDSPVFWYAPECLKECKFYYASDVWSFGVTLYELLTYCDSNQSPHMKFTELIGHTQG 1137

  Fly   734 --------ERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQT 783
                    |.::||..|.:|..|..|||.:||.||    |...:||.....|..:.||
Mouse  1138 QMTVLRLTELLERGERLPRPDRCPCEIYHLMKNCW----ETEASFRPTFQNLVPILQT 1191

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	45/220 (20%)
		SH3_Tec_like	346..399	CDD:212702	12/79 (15%)
		SH2_Tec_family	403..505	CDD:198188	26/142 (18%)
		PTKc_Tec_like	521..778	CDD:173637	94/281 (33%)
Tyk2	NP_001192241.1	FERM_F1	33..128	CDD:465733
		FERM_F2	146..292	CDD:436450
		Jak1_Phl	311..454	CDD:465552	19/95 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..391		4/17 (24%)
		SH2	459..557	CDD:472789	20/104 (19%)
		Protein Kinases, catalytic domain	612..887	CDD:473864	53/311 (17%)
		PTKc_Tyk2_rpt2	912..1194	CDD:270664	97/288 (34%)