Protein Alignment Btk and Ptk2b

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_059014.2
• Gene: Ptk2b / 50646
• RGDID: 628758
• Length: 1009
• Species: Rattus norvegicus
• Alignment Length: 415
• Identity: 132/415 - (31%)
• Similarity: 205/415 - (49%)
• Gaps: 62/415 - (14%)

  Fly   386 LGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAE---SLLKQGDKEGCFVVRKSSTKGLYTLS 447
            ||..|...|..:|..:|...|.....:....|.:.|   ||:....|:|   .:::|...:.||:
  Rat   322 LGIEGAPQSLSIKTSSLAEAENMADLIDGYCRLQGEHKGSLIIHAKKDG---EKRNSLPQIPTLN 383

  Fly   448 LHTKVPQSHVKHYHIKQNARCEYYLSEKHCCET-----IPDLINYHRHNSGGLACRLKSSPCDRP 507
            |.::  :||               |||....|:     |||                  ....||
  Rat   384 LESR--RSH---------------LSESCSIESDIYAEIPD------------------ETLRRP 413

  Fly   508 VPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRG----SIDTAVKMMKEGTM--SEDDF 566
            ..|..|::.:       :::|...||.|.||.|..|.:..    .|:.|||..|:...  :::.|
  Rat   414 GGPQYGVARE-------DVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKF 471

  Fly   567 IEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQV 631
            :.||.:|..|.||::|:|.|:. :..|.:||.|...:|.|.:||.|::.:|  .:..|:...:|:
  Rat   472 MSEAVIMKNLDHPHIVKLIGII-EEEPTWIVMELYPYGELGHYLERNKNSL--KVPTLVLYALQI 533

  Fly   632 SKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLN 696
            .|.|.|||..|.:|||:|.||.||.|...||:.||||:||:.|:.|..:..|:.||||..||.:|
  Rat   534 CKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESIN 598

  Fly   697 YTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWS 761
            :.||::.||||.:.|.||||.:.||.|:..|:|.:|:..:::|..|.||:.|...:|.:|..||.
  Rat   599 FRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPELCPPVLYTLMTRCWD 663

  Fly   762 HGPEERPAFRVLMDQLALVAQTLTD 786
            :.|.:||.|..|:..|:.:.|...|
  Rat   664 YDPSDRPRFTELVCSLSDIYQMERD 688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	4/12 (33%)
		SH2_Tec_family	403..505	CDD:198188	20/109 (18%)
		PTKc_Tec_like	521..778	CDD:173637	99/262 (38%)
Ptk2b	NP_059014.2	FERM_N_2	39..137	CDD:436229
		B41	41..254	CDD:214604
		FERM_C_FAK1	261..368	CDD:270011	11/45 (24%)
		PTKc_FAK	418..687	CDD:133187	102/278 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	702..725
		Interaction with TGFB1I1. /evidence=ECO:0000269|PubMed:9422762	801..1009
		Focal adhesion targeting (FAT)	868..1009
		Focal_AT	872..1001	CDD:460992