Protein Alignment Btk and Map3k9

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_038968663.1
• Gene: Map3k9 / 500690
• RGDID: 1562149
• Length: 1120
• Species: Rattus norvegicus
• Alignment Length: 486
• Identity: 120/486 - (24%)
• Similarity: 184/486 - (37%)
• Gaps: 166/486 - (34%)

  Fly   349 ALYPFKAIEGGDLSLEKNAEYEVID-DSQ----EHWWKVKDALGNVGYIPSNYVKPKALLGLERY 408
            |::.::|....:|:|......||:. |||    |.|| .......||..|||||.|::..
  Rat    52 AVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWW-TGQLNQRVGIFPSNYVTPRSAF----- 110

  Fly   409 EWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLS 473
                                                                    ::||:....
  Rat   111 --------------------------------------------------------SSRCQPGTE 119

  Fly   474 EKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFG 538
            :..|                              .||...|     ||...||.|.|.:|.|.||
  Rat   120 DPSC------------------------------YPPIQLL-----EIDFAELTLEEIIGIGGFG 149

  Fly   539 VVRRGKWRGSIDTAVKMMKEG-----TMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVT 598
            .|.|..|.|. :.|||..:..     :.:.::..:|||:...|:|||::.|.|||.|...:.:|.
  Rat   150 KVYRAFWVGD-EVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVM 213

  Fly   599 EYMKHGSLLNYLRRHEKTLIGNM---GLLLDMCIQVSKGMTYLERHN-----YIHRDLAARNCLV 655
            |:.:.|.|       .:.|.|..   .:|::..:|:::||.||  |:     .|||||.:.|...
  Rat   214 EFARGGPL-------NRVLSGKRVPPDILVNWAVQIARGMNYL--HDEAIVPVIHRDLKSSNSEC 269

  Fly   656 G----------------------------SENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPP 692
            |                            |...:|:.||||||........|:.||   ..|..|
  Rat   270 GELGWGEQHSLSLRLCEVLILQKVENGDLSNKTLKITDFGLAREWHRTTKMSAAGT---YAWMAP 331

  Fly   693 EVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEK-----PKSCAKEI 752
            ||:..:.||..||||:||||:||:.| |::|:..:....|.    .|:.:.|     |.:|.:..
  Rat   332 EVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVA----YGVAMNKLALPIPSTCPEPF 391

  Fly   753 YDVMKLCWSHGPEERPAFRVLMDQLALVAQT 783
            ..:|:.||:..|..||:|..::|||..:.::
  Rat   392 AKLMEDCWNPDPHSRPSFSSILDQLTTIEES 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	19/54 (35%)
		SH2_Tec_family	403..505	CDD:198188	3/101 (3%)
		PTKc_Tec_like	521..778	CDD:173637	92/302 (30%)
Map3k9	XP_038968663.1	SH3_MLK1-3	49..106	CDD:212992	19/54 (35%)
		STKc_MLK1	130..419	CDD:271047	95/311 (31%)