DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and ptk2b

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:XP_012819490.1 Gene:ptk2b / 496459 XenbaseID:XB-GENE-489525 Length:1017 Species:Xenopus tropicalis


Alignment Length:503 Identity:146/503 - (29%)
Similarity:232/503 - (46%) Gaps:73/503 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   291 CTPTSLQPQSSLTTFKQSP---TLLNGNGTLLDANM-PGGIPTPGTPNSKAKDNSHFVKLVVALY 351
            |....:...|:.|:..|..   .|..|....:|..: |.||....|.:||.          ....
 Frog   242 CITRFMNTLSTFTSIDQETYRCELAQGWSITVDLVIGPKGIRQLTTKDSKP----------TCFA 296

  Fly   352 PFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMS 416
            .||.|        |:.:..:::|.    |.:. .||..|......:|..:|...|.....:....
 Frog   297 EFKQI--------KSIKCSLLEDG----WALL-LLGISGAPQPLAIKTSSLAVAENMADLIDGYC 348

  Fly   417 RQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETI 481
            |.:.||      |:...|..|...:...:|      ||...:...::::...|....|......|
 Frog   349 RLQNES------KDSLIVNPKKDNEKRISL------PQIPTEEVQVRRSRLVEGNSMESDIYAEI 401

  Fly   482 PDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRG--- 543
            |::..                         ..|:::::.|...::.|...||.|.||.|..|   
 Frog   402 PEVTE-------------------------TKLTNNRFTISRSDVALGRILGEGFFGEVYDGVYV 441

  Fly   544 KWRG-SIDTAVKMMKEGTMSE--DDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGS 605
            |.:| .|:.|||..|....::  :.|:.||.:|..|.||::|:|.|:. :..||:||.|...:|.
 Frog   442 KPKGDKINVAVKTCKNDCAADVKEKFMSEAYLMRNLDHPHIVKLIGII-EDDPIWIVMELYPYGE 505

  Fly   606 LLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLAR 670
            |..||.:::.:| ..:.|:| ..:|:.|.:.|||..|.:|||:|.||.||.|...||:.||||:|
 Frog   506 LGQYLEKNKNSL-QVLSLIL-YSLQICKALAYLEGINCVHRDIAVRNILVASPECVKLGDFGLSR 568

  Fly   671 YVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVER 735
            |:.:::|..:..|:.||||..||.:|:.||:|.||||.:||.||||.:.||.|:..|:|.:|:..
 Frog   569 YLEEEEYYKASVTRLPIKWMAPESINFRRFTSASDVWMFGVCMWEILSFGKQPFFWLENKDVISV 633

  Fly   736 VQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQT 783
            :::|..|.||:.|...:|.:|..||::.|.|||.|..|:..|:.:.||
 Frog   634 IEKGDRLPKPEMCPPTLYTLMTRCWTYDPFERPKFTELVCSLSDIYQT 681

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 9/52 (17%)
SH2_Tec_family 403..505 CDD:198188 14/101 (14%)
PTKc_Tec_like 521..778 CDD:173637 104/262 (40%)
ptk2bXP_012819490.1 FERM_N_2 35..133 CDD:436229
B41 37..261 CDD:214604 4/18 (22%)
FERM_C_FAK1 257..364 CDD:270011 27/135 (20%)
PTKc_FAK 414..683 CDD:133187 107/271 (39%)
Focal_AT 880..1009 CDD:460992
Blue background indicates that the domain is not in the aligned region.

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