DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and grb2a

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_001007770.1 Gene:grb2a / 493609 ZFINID:ZDB-GENE-041121-1 Length:217 Species:Danio rerio


Alignment Length:218 Identity:51/218 - (23%)
Similarity:97/218 - (44%) Gaps:41/218 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   348 VALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYV 412
            :|.|.|||....:||.::....:|:::..:..|...:..|..|:||.||::.|.      :.|:.
Zfish     4 IAKYDFKATADDELSFKRGEILKVLNEECDQNWYKAELNGKEGFIPKNYIEMKP------HPWFY 62

  Fly   413 GDMSRQRAESLLKQGDKEGCFVVRKS-STKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKH 476
            |.:.|.:||.:|.:...:|.|::|:| |..|.::||:..   .:.|:|:.:.::...:|:|....
Zfish    63 GKIPRAKAEEMLNKQRHDGAFLIRESESAPGDFSLSVKF---GNDVQHFKVLRDGAGKYFLWVVK 124

  Fly   477 CCETIPDLINYHRHNSGGLACRLKSSPC----DRPVPPTAGLSHDKWEIHPMELMLMEELGSGQF 537
             ..::..|::|||..|..     ::.|.    ...||..:......::..|.|        .|:.
Zfish   125 -FNSLNSLVDYHRSTSVS-----RNQPIFLRDIEQVPQNSTYVQALFDFDPQE--------DGEL 175

  Fly   538 GVVRRGK------------WRGS 548
            | .|||.            |:|:
Zfish   176 G-FRRGDFIQVLDNSDPNWWKGA 197

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 15/50 (30%)
SH2_Tec_family 403..505 CDD:198188 24/106 (23%)
PTKc_Tec_like 521..778 CDD:173637 9/40 (23%)
grb2aNP_001007770.1 SH3_GRB2_N 1..56 CDD:212879 15/51 (29%)
SH2_Grb2_like 56..150 CDD:199828 25/108 (23%)
SH3_GRB2_C 160..212 CDD:212882 9/47 (19%)
Blue background indicates that the domain is not in the aligned region.

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