Protein Alignment Btk and yes1

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_001008186.1
• Gene: yes1 / 493548
• XenbaseID: XB-GENE-495082
• Length: 537
• Species: Xenopus tropicalis
• Alignment Length: 600
• Identity: 222/600 - (37%)
• Similarity: 317/600 - (52%)
• Gaps: 93/600 - (15%)

  Fly   184 EDSNTPKSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREANNNPS-NGSSPAQNSTRSISPN 247
            ||......||..|...||.::    |...|           :|..:|. .|.:|..|| .|::|
 Frog     8 EDKGPSIKYRTEPKPDSGSQY----GGDPT-----------QATQSPGIKGPAPNFNS-HSMTP- 55

  Fly   248 SSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLL 312
                                       .|||.|:...||.....:||.:.
 Frog    56 ---------------------------FGGSSGITPFGGASSIFSPTPVP--------------- 78

  Fly   313 NGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQE 377
                      .|||: |.|            |.:.||||.::|....|||..|...:::|::::.
 Frog    79 ----------YPGGL-TGG------------VTVFVALYDYEARTTEDLSFRKGERFQIINNTEG 120

  Fly   378 HWWKVKD-ALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAES-LLKQGDKEGCFVVRKS-S 439
            .||:.:. |.|..||||||||.|...:..|  |||.|.|.|:.||. ||..|::.|.|:||:| :
 Frog   121 DWWEARSIATGKTGYIPSNYVAPADSIQAE--EWYFGKMGRKDAERLLLNPGNQRGTFLVRESET 183

  Fly   440 TKGLYTLSLH--TKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSS 502
            |||.|:||:.  .:|...:||||.|::.....||::.:...|::..|:.::..::.||..|| ::
 Frog   184 TKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFESLQKLVKHYSEHADGLCYRL-TT 247

  Fly   503 PCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFI 567
            .|....|.|.|||.|.|||....|.|..:||.|.||.|..|.|.|:...|:|.:|.|||..:.|:
 Frog   248 VCPTVKPQTQGLSKDAWEIPRESLRLDVKLGQGCFGEVWIGTWNGTTKVAIKTLKPGTMMPEAFL 312

  Fly   568 EEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVS 632
            :||::|.||:|..||.||.|.|: .|||||||||..||||::|:..:...: .:..|:||..|::
 Frog   313 QEAQIMKKLRHDKLVPLYAVVSE-EPIYIVTEYMTKGSLLDFLKEGDGKYL-KLPQLVDMAAQIA 375

  Fly   633 KGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNY 697
            .||.|:||.|||||||.|.|.|||...|.|:|||||||.:.|::||:..|.||||||..||...|
 Frog   376 DGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 440

  Fly   698 TRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSH 762
            .||:.|||||::|:|:.|:.|.|::||..:.|.||:|:|:||..:..|:.|.:.::::|||||..
 Frog   441 GRFTIKSDVWSFGILLTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMKLCWKK 505

  Fly   763 GPEERPAFRVLMDQL 777
            .|:|||.|..:...|
 Frog   506 DPDERPTFEYIQSFL 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	9/37 (24%)
		SH3_Tec_like	346..399	CDD:212702	22/53 (42%)
		SH2_Tec_family	403..505	CDD:198188	37/105 (35%)
		PTKc_Tec_like	521..778	CDD:173637	121/256 (47%)
yes1	NP_001008186.1	SH3_Yes	88..145	CDD:212940	23/56 (41%)
		SH2_Src_family	148..247	CDD:199827	37/101 (37%)
		PTKc_Yes	258..536	CDD:270654	127/264 (48%)