Protein Alignment Btk and nck1

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_001008101.1
• Gene: nck1 / 493463
• XenbaseID: XB-GENE-6085807
• Length: 377
• Species: Xenopus tropicalis
• Alignment Length: 489
• Identity: 94/489 - (19%)
• Similarity: 155/489 - (31%)
• Gaps: 193/489 - (39%)

  Fly    36 SERLY--DVVKSGSMVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVR 98
            :|||:  |..||...|:.:.||..|.|.||..|.....|.:.    |:|::.....|::..|
 Frog    27 NERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASI----VKNLKDTLGIGKVKRK--- 84

  Fly    99 LVEEATVSGEGGDPFAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLY 163
                         |..||           |||.....|.:..          :.....:|.|..:
 Frog    85 -------------PSMPD-----------SASTADDSLPDAE----------RLYDLNMPAYVKF 115

  Fly   164 VIANSEKERSEWIRA----IRQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWR 224
            .......:....::.    :.:.|.|.                 |                  ||
 Frog   116 TYTAERDDELSLVKGTKVIVMEKCSDG-----------------W------------------WR 145

  Fly   225 EANNNPSNGSSPAQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGG 289
                                                  ||..|.||
 Frog   146 --------------------------------------GSYNGRVG------------------- 153

  Fly   290 SCTPTSLQPQSSLTTFKQSPTLLNGN--GTLLD--ANMPGGIPTPGTPNSKAKDNSHFVKLVVAL 350
                  ..|.:.:|....||   :|:  |||.:  |.:...:           :|...:.:|.||
 Frog   154 ------WFPSNYVTEENDSP---SGDQVGTLTEKLAAVVNNL-----------NNGRSLHVVQAL 198

  Fly   351 YPFKAIEGGDLSLEKNAEYEVID--DSQEHWWKVKDALGNVGYIPSNYVK--------------- 398
            |||.:....:|:.||....:||:  ::...|||.:.:.|.||.:|.|||.
 Frog   199 YPFSSSNEEELNFEKGEVMDVIEKPENDPEWWKCRKSNGLVGLVPKNYVTIMQNFQPTPSFEPLP 263

  Fly   399 -------PKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKS-STKGLYTLSLHTKVPQS 455
                   |.|.......:||.|.::|.:||..|.:...||.|::|.| |:...:::||..   |.
 Frog   264 PRCDYIGPSASGRFAGNQWYYGKVTRHQAEMALNERGNEGDFLIRDSESSPNDFSVSLKA---QG 325

  Fly   456 HVKHYHIKQNARCEYYLSEKHCCETIPDLINYHR 489
            ..||:.: |...|.|.:.::. ..|:.:|:.:::
 Frog   326 KNKHFKV-QMKDCMYCIGQRK-FSTMEELVEHYK 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	27/181 (15%)
		SH3_Tec_like	346..399	CDD:212702	21/76 (28%)
		SH2_Tec_family	403..505	CDD:198188	23/88 (26%)
		PTKc_Tec_like	521..778	CDD:173637
nck1	NP_001008101.1	SH3_Nck1_1	4..62	CDD:212833	14/34 (41%)
		SH3_Nck1_2	108..162	CDD:212834	13/151 (9%)
		SH3_Nck1_3	193..249	CDD:212837	21/55 (38%)
		SH2_Nck1	280..376	CDD:198271	23/83 (28%)