DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and Src64B

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	216/539 - (40%)
Similarity:	296/539 - (54%)	Gaps:	55/539 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 FSLQH-NSSGSLGGGVGGGLG----GGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLNG 314
            |...| ||||  ||.:||.||    .||||        ....||   .|.      .:.|..:.|
  Fly    30 FGQTHINSSG--GGNMGGVLGQKHNNGGSL--------DSRYTP---DPN------HRGPLKIGG 75

  Fly   315 NGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHW 379
            .|. :|...|...|| |.|....|      ::|||||.:|:.:..|||..|....|||||::..|
  Fly    76 KGG-VDIIRPRTTPT-GVPGVVLK------RVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDW 132

  Fly   380 WKVKD-ALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAES-LLKQGDKEGCFVVRKS--ST 440
            |:|.: .....|.||.|:|..:..:..|  :|:..::.|:.|:. ||.:.:..|.|:||.|  :.
  Fly   133 WRVVNLTTRQEGLIPLNFVAEERSVNSE--DWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNP 195

  Fly   441 KGLYTLSLHTKVPQS--HVKHYHIKQNARCEYYLSEKHCCETIPDL----INYHRHNSGGLACRL 499
            .| |:||:.......  |||||.||......||::..   :|.|.|    :.|.:.|:.|| |.:
  Fly   196 NG-YSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATN---QTFPSLQALVMAYSKENALGL-CHI 255

  Fly   500 KSSPCDRPVPPTAGLS---HDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTM 561
            .|.||.:|.|....|.   .||:||...|:.|:.:||.|.||.|..||||.|||.|||.::||||
  Fly   256 LSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTM 320

  Fly   562 SEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLD 626
            |...|::||.:|.|.:|..||.||.|||:..|||||.|||..||||::||..:...: :...|:.
  Fly   321 STAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYL-HFEDLIY 384

  Fly   627 MCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAP 691
            :..||:.||.|||....|||||||||.|:|..||.|:.||||||.:.||:|....|::||:||..
  Fly   385 IATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTA 449

  Fly   692 PEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKS--CAKEIYD 754
            ||.:.|.:||.|||||:||:|:.|:||.|::||..:.:.||:|.::||..:.||.:  ....||.
  Fly   450 PEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQ 514

  Fly   755 VMKLCWSHGPEERPAFRVL 773
            ::..||...||:||.|..|
  Fly   515 LLLQCWDAVPEKRPTFEFL 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	23/53 (43%)
		SH2_Tec_family	403..505	CDD:198188	34/110 (31%)
		PTKc_Tec_like	521..778	CDD:173637	123/255 (48%)
		Pkinase_Tyr	526..777	CDD:285015	121/250 (48%)
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	21/50 (42%)
		SH2_Src_family	158..259	CDD:199827	33/107 (31%)
		STYKc	285..537	CDD:214568	121/250 (48%)
		PTKc_Src_like	289..538	CDD:270630	120/246 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468343
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	1	0.900	-	-		E2759_KOG0197
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17578at33392
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850