Protein Alignment Btk and zap70

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_001006825.1
• Gene: zap70 / 448557
• XenbaseID: XB-GENE-956409
• Length: 609
• Species: Xenopus tropicalis
• Alignment Length: 453
• Identity: 155/453 - (34%)
• Similarity: 233/453 - (51%)
• Gaps: 71/453 - (15%)

  Fly   380 WKVK-DALGNVGYIPSNYVKPKALLGL---ERYEWYVGDMSRQRAESLLKQG-DKEGCFVVRKSS 439
            ||:: |||...  |.|...:.:.|:..   ||..||.|.:||..||..|..| ..:|.|::|:..
 Frog   131 WKLEGDALEQA--IISQAPQVEKLIATTAHERMAWYHGTISRDEAERKLYSGAQPDGKFLMRERK 193

  Fly   440 TKGLYTLS-LHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSS- 502
            ..|.|.|| ::.|.    |.||.|.|:...:|.:.|....:|:..|:.|.:..|.|:...||.|
 Frog   194 ENGTYALSVMYGKT----VYHYKIDQDKSGKYSIPEGTKFDTLWQLVEYLKLKSDGIMAVLKESC 254

  Fly   503 --PCDRPVPPTA----------------GLSHD----KWEIHPM--------------------- 524
              .|...:.|.|                |.:.:    |..|.||
 Frog   255 PNSCTFSIAPAAAPPSLPKIRQAASNSDGYTPEPFIGKSRILPMDTSVYESPYSDPEELKERKLF 319

  Fly   525 ---ELMLME--ELGSGQFGVVRRGKW---RGSIDTAVKMMK--EGTMSEDDFIEEAKVMTKLQHP 579
               ||:|::  |||||.||.|::|.:   :..||.|:|::|  :.....|:.::||::|.:|.:|
 Frog   320 VKRELLLIDEVELGSGNFGCVKKGVYKLKKRQIDVAIKVLKVQDEKNVRDEMMKEAEIMHQLDNP 384

  Fly   580 NLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYI 644
            .:|::.|||.... :.:|.| |..|..||.....:|.:| .|..::::..|||.||.|||..|::
 Frog   385 YIVRMIGVCEAEN-LMLVME-MASGGPLNKFLGAKKDVI-PMSNIVELMHQVSIGMKYLEGKNFV 446

  Fly   645 HRDLAARNCLVGSENVVKVADFGLARYVL--DDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVW 707
            ||||||||.|:.:::..|::||||::.:.  |..|.:....|:|:||..||.:||.:|||:||||
 Frog   447 HRDLAARNVLMVNQHYAKISDFGLSKALAADDSYYKAKSFGKWPLKWYAPECINYRKFSSRSDVW 511

  Fly   708 AYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAF 770
            :||:.|||.||.|:.||.:||.|||:..::|...|..|..|..|:|.||..||....|:||.|
 Frog   512 SYGITMWEAFTYGQKPYKKLKGTEVMSFIERNERLACPAGCPPEMYQVMLDCWIFKMEDRPNF 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	7/19 (37%)
		SH2_Tec_family	403..505	CDD:198188	34/109 (31%)
		PTKc_Tec_like	521..778	CDD:173637	108/283 (38%)
zap70	NP_001006825.1	SH2_N-SH2_Zap70_Syk_like	8..111	CDD:198191
		SH2_C-SH2_Zap70	152..256	CDD:198265	35/107 (33%)
		Protein Kinases, catalytic domain	321..589	CDD:473864	105/257 (41%)