DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and lyn

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_001004543.1	Gene:	lyn / 447804	ZFINID:	ZDB-GENE-040912-7	Length:	510	Species:	Danio rerio

Alignment Length:	480	Identity:	196/480 - (40%)
Similarity:	283/480 - (58%)	Gaps:	26/480 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 TTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNA 367
            |::|  |.:.:.|..||          ||....|.::..   |:||||||::||...||..:|..
Zfish    37 TSYK--PPITSQNAGLL----------PGQVFQKMEEKE---KIVVALYPYEAIHADDLGFKKGE 86

  Fly   368 EYEVIDDSQEHWWKVKD-ALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAE-SLLKQGDKE 430
            :.::|::..| |||.:. .....|:||||||.....  :|..||:..|::|:.|| .||...:|.
Zfish    87 KLKIIEEHGE-WWKARSLTTRKEGFIPSNYVAEADT--METEEWFYKDITRKDAERQLLAPANKP 148

  Fly   431 GCFVVRKSST-KGLYTLSLHTKVPQSH--VKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNS 492
            |.:::|:|.| ||.|:||:.....|..  ||||.|:......||:|.|.....|..:|.::...|
Zfish   149 GSYLIRESETSKGSYSLSIRDVDAQGQDVVKHYKIRSLDNGGYYISPKITFSDISSMIKHYHKQS 213

  Fly   493 GGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMK 557
            .|| ||.....|::| ........|.|||....:.::::||:||||.|....:..|...|||.:|
Zfish   214 DGL-CRKLDKACEKP-KAQKPWDKDAWEISKDSIKMVKKLGAGQFGEVWMAFYNNSTKVAVKTLK 276

  Fly   558 EGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMG 622
            .||||.:.|:|||.:|..|||..||:||.|.:|..||||:||||.:||||::|:....:.| .:.
Zfish   277 PGTMSVEAFLEEANLMKTLQHDRLVRLYAVVTKTEPIYIITEYMANGSLLDFLKSQAGSKI-QLP 340

  Fly   623 LLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPI 687
            .|:|...|:::||.|:|:.|||||||.|.|.||....:.|:|||||||.:.|||||:..|.||||
Zfish   341 KLIDFSAQIAEGMAYIEKKNYIHRDLRAANVLVSEMLLCKIADFGLARVIEDDQYTAREGAKFPI 405

  Fly   688 KWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEI 752
            ||..||.:||..|:.|||:|::|||::||.|.||:||..:.|:||:..||||..:.:|::|..|:
Zfish   406 KWTAPEAINYGSFTIKSDMWSFGVLLYEIITYGKIPYPGMSNSEVMSSVQRGYRMPRPENCPVEL 470

  Fly   753 YDVMKLCWSHGPEERPAFRVLMDQL 777
            |::|..||.:.||:||.|..:...|
Zfish   471 YEIMTTCWKNKPEDRPTFDYIQSVL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	23/53 (43%)
		SH2_Tec_family	403..505	CDD:198188	36/105 (34%)
		PTKc_Tec_like	521..778	CDD:173637	122/257 (47%)
		Pkinase_Tyr	526..777	CDD:285015	120/250 (48%)
lyn	NP_001004543.1	SH3_Lyn	65..120	CDD:212937	23/55 (42%)
		SH2_Src_Lyn	123..223	CDD:198227	36/100 (36%)
		PTKc_Lyn	237..508	CDD:270657	124/260 (48%)
		Pkinase_Tyr	245..495	CDD:285015	120/250 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910