DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Btk29A and Shark

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster

Alignment Length:	909	Identity:	210/909 - (23%)
Similarity:	330/909 - (36%)	Gaps:	285/909 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 SMVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVRLVEE-------AT 104
            :::.||.:|.....|      |||.|..:..||.:|.:.:.   .:||..:...|:       |.
  Fly   122 NLLHRATSKNESKVV------FELLKCGYRNFDAKNQDGQT---ALHLAALHSDEDILKHLLNAK 177

  Fly   105 VSGEGGDPF-------APDGYPFQVGYCEISASAN--SHQLENG--------------------- 139
            |.....|.|       |....|.......|||.||  ...::||
  Fly   178 VQVNSSDSFGCQPLHYAARSKPASFIRTLISAQANVQGRNIDNGYVPLHEAAKHGNLEAVQELLL 242

  Fly   140 ---------NGGGSGVGIEGQQSGRAVPQYTL-YVIANSEKERSEWIRAIRQVCEDSNTPKSYRY 194
                     :.|.....:..:....||.::.| |.:..:...|.:|                  |
  Fly   243 AEAPPLPRTSSGEFPFDLAKEAGQTAVEEFLLNYKLPPANTTRDQW------------------Y 289

  Fly   195 HPGLWSGKKWSCCKGLSR---------TTFGCRAAAHWREANNNPSNGSSPAQNS-TRSISPNSS 249
            |..|...:..:..|..::         .|.||....:          ..|||.:. ..::..:..
  Fly   290 HGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRY----------SESPAASGLVLTLLCDQV 344

  Fly   250 TTN---SQFSLQHNSSGSLGGGVGGGLGGGG-------------------------SLGLGGGGG 286
            ..|   ||..|..|         |..:..||                         |.||
  Fly   345 VKNFRISQADLYQN---------GNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGL----- 395

  Fly   287 GGGSCTPTSL------QPQSSLTTFKQSPTLLNGNGTLLDANM------PGGIPTPGTPNS---- 335
                  |.||      ||:..:.:|          .|:..:||      |...|||.:|:|
  Fly   396 ------PVSLKYPVPPQPKPEVPSF----------ATIPRSNMKPKAASPATPPTPVSPHSHHQH 444

  Fly   336 -----------KAKDNSHFVKLVVAL-YPFKAIEGGDL-SLEKNAEYEVIDDSQEHWWKVKDAL- 386
                       |.|:||..:...:.| .|.||:  .|: ||.||.......||:.   .|..:|
  Fly   445 PHVPALTITKKKQKENSSSMFNTLRLTSPKKAL--FDMNSLRKNKSKGKRSDSES---SVSGSLA 504

  Fly   387 --------------------------------------GNVGYIPSNY------VKPKALLGLER 407
                                                  |.|..:|.|.      :.|.|......
  Fly   505 GTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAE 569

  Fly   408 YEWYVGD---MSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCE 469
            .|::...   :.|:||...:..|.:....|        |..|....|.| :..:...:..||..|
  Fly   570 VEYFTKSDVAIERERAGQWIGNGYQPTMDV--------LSLLDQQIKAP-AVARLNSLGPNASTE 625

  Fly   470 YYLSEKHCCETIPDLINY-HRHNSGGLACRLKSSPCDRPVPPTA---GLSHDKWEIHPMELMLME 530
                        .::.:| ||..||            .|..|:|   ..:..::.|.|.:|:|..
  Fly   626 ------------SEMASYLHRKCSG------------TPSTPSATEVEAAKLRFFIEPEKLVLDR 666

  Fly   531 ELGSGQFGVVRRGKW---------RGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYG 586
            |:|.|:||.|..| |         ...::.|:||:.:...::.:|:.||.||.:|:|..:|:|.|
  Fly   667 EIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIG 730

  Fly   587 VCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAAR 651
            : :|...:.:|.|....||:|.|:..|...:..|..|.: ...|::.||.|||..:::|||||||
  Fly   731 I-AKGEMLMMVQELAPLGSMLQYILDHGHEITANAELKV-WASQIACGMHYLESQHFVHRDLAAR 793

  Fly   652 NCLVGSENVVKVADFGLARYVL--DDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMW 714
            |.|:.:.:..|::|||::|.:.  ..:|..:.|.::||:|..||..|...||..||||::||.:|
  Fly   794 NILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIW 858

  Fly   715 EIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLA 778
            |:|:.|..|||.:.|.:.::.|..|..|.:|..|...||.||:.||...|::||.|..|.:..|
  Fly   859 EMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFFA 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944	41/230 (18%)
		SH3_Tec_like	346..399	CDD:212702	17/99 (17%)
		SH2_Tec_family	403..505	CDD:198188	18/105 (17%)
		PTKc_Tec_like	521..778	CDD:173637	95/267 (36%)
		Pkinase_Tyr	526..777	CDD:285015	93/261 (36%)
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		Ank_2	<112..184	CDD:289560	16/70 (23%)
		ANK	117..241	CDD:238125	27/127 (21%)
		ANK repeat	124..151	CDD:293786	10/32 (31%)
		ANK repeat	153..184	CDD:293786	5/33 (15%)
		Ank_2	158..247	CDD:289560	16/88 (18%)
		ANK repeat	186..217	CDD:293786	8/30 (27%)
		ANK repeat	220..245	CDD:293786	2/24 (8%)
		Ank_4	224..274	CDD:290365	3/49 (6%)
		SH2_Cterm_shark_like	287..395	CDD:198211	20/144 (14%)
		TyrKc	662..921	CDD:197581	93/261 (36%)
		PTKc_Syk_like	666..926	CDD:270650	92/260 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468348
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840