Protein Alignment Btk and Cad96Ca

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_651349.1
• Gene: Cad96Ca / 43026
• FlyBaseID: FBgn0022800
• Length: 773
• Species: Drosophila melanogaster
• Alignment Length: 878
• Identity: 215/878 - (24%)
• Similarity: 313/878 - (35%)
• Gaps: 228/878 - (25%)

  Fly     6 HRNSHVNGSIKSSSSLRS-SSKSFQAKMDLMSERLYDVVKSGSMVKRAQNKKRFTPVNYKHRWFE 69
            |.::|.:..|.....|.| ..:|....:.:::..:..::   |....|.|:.. .|:.|
  Fly     4 HHHNHESRIIHCRKQLTSWRRRSLLLTIIVVTATVVSLI---SQEAEAHNQNA-PPILY------ 58

  Fly    70 LTKRTFSYFDVENVERRRERGRIH-------LKGVRLVEEATVSGEGG--DPFAPDGYPFQVGYC 125
            :.:|.:...:.|.|.:..:|.|..       :.|:    |...|..||  |...|:..|||:
  Fly    59 VRERNWRISETEKVGQIIDRVRAEDPDGDDLIFGI----EPRFSLPGGENDASPPEKIPFQI--- 116

  Fly   126 EISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIAN---------------SEKERSEW 175
                     ..|.|     .|.:....:|||...:.:|:...               .|:|.|..
  Fly   117 ---------DRETG-----VVTLNESLAGRAGQNFLIYITVTDGSYTAKNEVFINILGERENSSG 167

  Fly   176 IR---AIRQVCED-SNTPKSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREANNNPSNGSSP 236
            .|   :|..|..: |.....:...||:.|.:     .||..:    |....:.....|...|..|
  Fly   168 YRPQTSISNVVHNISQFLPRFDQLPGVQSIR-----NGLPNS----RPGGWYPPVPQNNIFGPPP 223

  Fly   237 AQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSS 301
            ..|:.....||......:.|.:......                         ..|||:....||
  Fly   224 FGNNYPPPPPNIPGVRGEQSGEEEQPDE-------------------------EVTPTTPVRISS 263

  Fly   302 LT---TFKQSPTLLNGNGTLLDANMPGGIPTP--GTPNSKAKDNSHFVKLVVALYPFKAIEGG-- 359
            .|   ..|.:|...| |.|.:::.:|....||  |..|:.:...:.| .|.....|.....||
  Fly   264 TTPKSRTKLTPITAN-NSTRVESAIPAETTTPSGGHHNNSSSPITIF-SLKSGTIPIVVTVGGFF 326

  Fly   360 ------------------DLSLEKNAEYE--------------VIDDSQE----HWWKVKDALGN 388
                              ..:|:|..|.|              :.|||:.    ..|:...|..|
  Fly   327 VAIAVLLAYLCRRRLCAISRTLKKTKEKEELAKKSNQSQLSSTLTDDSRNSMVMQQWQGPVAFAN 391

  Fly   389 VGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVP 453
             .|:|                |                         .:....|:.|..|.|.|.
  Fly   392 -RYVP----------------W-------------------------ERDQQMGIATSQLSTGVT 414

  Fly   454 QSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSH-D 517
            ...|....:......|...:....|.|            ||      :.....|....||.:: |
  Fly   415 NGGVSSPGVPSPGTGEPGSNLGPGCLT------------GG------AGSSGAPENAFAGEANCD 461

  Fly   518 KWEIHPMELMLMEELGSGQFGVVRRGKWR----------GSIDTAVKMMKEGTMSED--DFIEEA 570
            :||.....|.....||.|.||.|    ||          |....|||.:||.....|  |.:.|.
  Fly   462 RWEFPRYRLKFFNILGEGAFGQV----WRCEATNINGNEGITTVAVKTLKESATEVDRKDLLSEL 522

  Fly   571 KVMTKLQ-HPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLR-----RHEKTLIGNMGL-----L 624
            :||..|: |.|:|.|.|.|:...|.:::.||:..|.|..|||     ||.....|...:     |
  Fly   523 EVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSRAERHYGNTHGKSNVLTSCDL 587

  Fly   625 LDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQ-YTSSGGTKFPIK 688
            .....||:|||.||.....|||||||||.|:..::..||||||.||.|:..: |......|.||:
  Fly   588 TSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIR 652

  Fly   689 WAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIY 753
            |...|.|....||.|||:|::|:|||||.|.|..||..:...:|:.:|:.|..||||:.|.:|:|
  Fly   653 WMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELY 717

  Fly   754 DVMKLCWSHGPEERPAFRVLMDQLALVAQTLTD 786
            ::|..||||.|:|||.|..::..|..:..|..|
  Fly   718 NIMYYCWSHDPQERPLFAEIIQMLDKLLHTEMD 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	40/205 (20%)
		SH3_Tec_like	346..399	CDD:212702	16/90 (18%)
		SH2_Tec_family	403..505	CDD:198188	12/101 (12%)
		PTKc_Tec_like	521..778	CDD:173637	108/280 (39%)
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	22/119 (18%)
		PTKc	474..742	CDD:270623	107/271 (39%)