DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Btk and MAP3K11

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_002410.1 Gene:MAP3K11 / 4296 HGNCID:6850 Length:847 Species:Homo sapiens


Alignment Length:544 Identity:132/544 - (24%)
Similarity:191/544 - (35%) Gaps:200/544 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   273 LGGGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKA 337
            ||.....|.||||||||                                         |.|....
Human    13 LGSWNGSGSGGGGGGGG-----------------------------------------GRPEGSP 36

  Fly   338 KDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVID-----DSQEHWWKVKDALGNVGYIPSNYV 397
            |...:...:..||:.::.....:|:|.|....||:.     ...|.|| .....|.||..|||||
Human    37 KAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWW-AGQVGGQVGIFPSNYV 100

  Fly   398 KPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHI 462
            .                                                                
Human   101 S---------------------------------------------------------------- 101

  Fly   463 KQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELM 527
                                        ..||      ..||:     .|..         .||.
Human   102 ----------------------------RGGG------PPPCE-----VASF---------QELR 118

  Fly   528 LMEELGSGQFGVVRRGKWRGSIDTAVKMMKEG-----TMSEDDFIEEAKVMTKLQHPNLVQLYGV 587
            |.|.:|.|.||.|.||.|||.: .|||..::.     :::.:...:||::...|.|||::.|..|
Human   119 LEEVIGIGGFGKVYRGSWRGEL-VAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAV 182

  Fly   588 CSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNM---GLLLDMCIQVSKGMTYLERH---NYIHR 646
            |.:...:.:|.||...|.|       .:.|.|..   .:|::..:|:::||.||...   ..|||
Human   183 CLEEPNLCLVMEYAAGGPL-------SRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHR 240

  Fly   647 DLAARNCL----VGSENV----VKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSK 703
            ||.:.|.|    :.|:::    :|:.||||||........|:.||   ..|..|||:..:.||..
Human   241 DLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGT---YAWMAPEVIKASTFSKG 302

  Fly   704 SDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEK-----PKSCAKEIYDVMKLCWSHG 763
            ||||::|||:||:.| |::||..:....|.    .|:.:.|     |.:|.:....:|..||:..
Human   303 SDVWSFGVLLWELLT-GEVPYRGIDCLAVA----YGVAVNKLTLPIPSTCPEPFAQLMADCWAQD 362

  Fly   764 PEERPAFRVLMDQL-ALVAQTLTD 786
            |..||.|..::.|| ||.||.|.:
Human   363 PHRRPDFASILQQLEALEAQVLRE 386

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 18/57 (32%)
SH2_Tec_family 403..505 CDD:198188 3/101 (3%)
PTKc_Tec_like 521..778 CDD:173637 90/281 (32%)
MAP3K11NP_002410.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 11..38 13/65 (20%)
SH3_MLK1-3 45..102 CDD:212992 18/149 (12%)
STKc_MLK3 113..379 CDD:271049 90/290 (31%)
Leucine-zipper 1 403..424
Leucine-zipper 2 438..459
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..643
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 655..847
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.