Protein Alignment Btk and MAP3K10

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_011525283.1
• Gene: MAP3K10 / 4294
• HGNCID: 6849
• Length: 962
• Species: Homo sapiens
• Alignment Length: 474
• Identity: 118/474 - (24%)
• Similarity: 181/474 - (38%)
• Gaps: 164/474 - (34%)

  Fly   349 ALYPFKAIEGGDLSLEKNAEYEVID-----DSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERY 408
            |::.::|....:|:|.:....:|:.     ...|.||..:...|.||..|||||.|.|
Human    23 AVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGA------- 80

  Fly   409 EWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLS 473
                                        .::..||
Human    81 ----------------------------PAAPAGL------------------------------ 87

  Fly   474 EKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFG 538
                  .:|..|.:|                                    ||.|.|.:|.|.||
Human    88 ------QLPQEIPFH------------------------------------ELQLEEIIGVGGFG 110

  Fly   539 VVRRGKWRGSIDTAVKMM-----KEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVT 598
            .|.|..|||. :.|||..     |:..::.:...:||::...|||||::.|.|.|.....:.:|.
Human   111 KVYRALWRGE-EVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVM 174

  Fly   599 EYMKHGSLLNYLRRHEKTLIGNM---GLLLDMCIQVSKGMTYLERHN-----YIHRDLAARNCLV 655
            ||.:.|:|       .:.|.|..   .:|::..:||::||.||  ||     .|||||.:.|.|:
Human   175 EYARGGAL-------SRVLAGRRVPPHVLVNWAVQVARGMNYL--HNDAPVPIIHRDLKSINILI 230

  Fly   656 --GSEN------VVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVL 712
              ..||      |:|:.||||||........|:.||   ..|..|||:..:.||..||||::|||
Human   231 LEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGT---YAWMAPEVIRLSLFSKSSDVWSFGVL 292

  Fly   713 MWEIFTCGKMPYGRLKNTEVVERVQRGIILEK-----PKSCAKEIYDVM--------KLCWSHGP 764
            :||:.| |::||..:....|.    .|:.:.|     |.:|.:....::        :.||...|
Human   293 LWELLT-GEVPYREIDALAVA----YGVAMNKLTLPIPSTCPEPFARLLEGEPGPRDEECWDPDP 352

  Fly   765 EERPAFRVLMDQLALVAQT 783
            ..||.|..::.:|.::.|:
Human   353 HGRPDFGSILKRLEVIEQS 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	16/54 (30%)
		SH2_Tec_family	403..505	CDD:198188	5/101 (5%)
		PTKc_Tec_like	521..778	CDD:173637	93/290 (32%)
MAP3K10	XP_011525283.1	SH3_MLK1-3	20..76	CDD:212992	14/52 (27%)
		Protein Kinases, catalytic domain	103..368	CDD:473864	90/282 (32%)