DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and MATK

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_002369.2	Gene:	MATK / 4145	HGNCID:	6906	Length:	508	Species:	Homo sapiens

Alignment Length:	457	Identity:	149/457 - (32%)
Similarity:	228/457 - (49%)	Gaps:	79/457 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   359 GDLSLEKNAEYEVIDDSQ-EHWWKVK-DALGNVGYIPSNYVKPKALLG----LERYEWYVGDMSR 417
            |:|:..|.....:::..: :.|::|| ...|..|.:.:..::.:..|.    |....|:.|.:|.
Human    66 GELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISG 130

  Fly   418 QRAESLLKQGDKEGCFVVRKSST-KGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETI 481
            |.|...| |..::|.|:||:|:. .|.|.|                              |....
Human   131 QEAVQQL-QPPEDGLFLVRESARHPGDYVL------------------------------CVSFG 164

  Fly   482 PDLINYH-RHNSGGLA-------CRL----------KSSPCDRPVPP---------TAGLSHDKW 519
            .|:|:|. .|..|.|.       |.|          |.:.|.:.|.|         ...|:...|
Human   165 RDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGW 229

  Fly   520 EIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQL 584
            .::...|.|..::|.|:||.|.:|::.|. ..|||.:| ..::...|::|..||||:||.|||:|
Human   230 LLNLQHLTLGAQIGEGEFGAVLQGEYLGQ-KVAVKNIK-CDVTAQAFLDETAVMTKMQHENLVRL 292

  Fly   585 YGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLA 649
            .||. .|:.:|||.|::..|:|:|:||...:.|: |...||...:.|::||.|||....:|||||
Human   293 LGVI-LHQGLYIVMEHVSKGNLVNFLRTRGRALV-NTAQLLQFSLHVAEGMEYLESKKLVHRDLA 355

  Fly   650 ARNCLVGSENVVKVADFGLA---RYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGV 711
            |||.||..:.|.||:|||||   |..||       .::.|:||..||.|.:.:|:||||||::||
Human   356 ARNILVSEDLVAKVSDFGLAKAERKGLD-------SSRLPVKWTAPEALKHGKFTSKSDVWSFGV 413

  Fly   712 LMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQ 776
            |:||:|:.|:.||.::...||.|.|::|..:|.|:.|...::.:|..||...|..||.||.|.::
Human   414 LLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEK 478

  Fly   777 LA 778
            ||
Human   479 LA 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	8/41 (20%)
		SH2_Tec_family	403..505	CDD:198188	27/124 (22%)
		PTKc_Tec_like	521..778	CDD:173637	107/259 (41%)
		Pkinase_Tyr	526..777	CDD:285015	107/253 (42%)
MATK	NP_002369.2	SH3_CHK	51..109	CDD:212745	8/42 (19%)
		SH3 domain	55..106		8/39 (21%)
		SH2_csk_like	119..216	CDD:198190	28/127 (22%)
		SH2 domain	123..213		28/120 (23%)
		PTKc_Chk	229..482	CDD:270666	110/263 (42%)
		catalytic domain	236..479		107/253 (42%)
		STYKc	236..479	CDD:214568	107/253 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810