DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and lck

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_001001596.1 Gene:lck / 414333 ZFINID:ZDB-GENE-040617-1 Length:503 Species:Danio rerio


Alignment Length:460 Identity:178/460 - (38%)
Similarity:264/460 - (57%) Gaps:20/460 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly   327 IPTPG----TPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDAL- 386
            ||.|.    .|:|...:|     ||||:|.:......||..||..:.:::|.....|:..:... 
Zfish    39 IPYPSQYTPPPSSPLPEN-----LVVAIYKYDPAHSDDLGFEKGEKMKILDCDDPEWYMAESLFT 98

  Fly   387 GNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRA-ESLLKQGDKEGCFVVRKSSTK-GLYTLSLH 449
            |..||||.|:|  ..|..:|...|:..::||..| ..||..|:.:|.|::|:|.|: |.:::|:.
Zfish    99 GQRGYIPKNFV--AKLNSMETEPWFYKNLSRNDAMRQLLAPGNTQGSFLIRESETQPGSFSISVR 161

  Fly   450 TKVPQSH--VKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTA 512
            ...|...  :|||.|:......:|::.|....::.:|:.::...:.||..|| ..||....|...
Zfish   162 DLDPMQGDIIKHYRIRNMDAGGFYITNKISFNSLSELVKHYSREADGLCTRL-VKPCQTRAPQKP 225

  Fly   513 GLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQ 577
            .. .|:||:....|.|...||.||||.|..|.:..:...|:|.:|.||||...|:.||.:|..||
Zfish   226 WW-QDEWEVPRESLKLERRLGQGQFGEVWMGLYNNNRQVAIKSLKPGTMSISAFLAEANLMKSLQ 289

  Fly   578 HPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHN 642
            ||.||:|:.|.:: .||||:||||::|||:::|:..|.:.| .:..|:||..||::||.|:|:.|
Zfish   290 HPRLVRLFAVVTQ-EPIYIITEYMENGSLVDFLKTPEGSDI-PINTLIDMAAQVAEGMAYVEQKN 352

  Fly   643 YIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVW 707
            ||||||.|.|.||..|...|:|||||||.:.:::||:..|.||||||..||.:||..||.|||||
Zfish   353 YIHRDLRAANILVSHELTCKIADFGLARLIKNNEYTAREGAKFPIKWTAPEAINYGTFSIKSDVW 417

  Fly   708 AYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRV 772
            ::|||:.||.|.|::||..:.|.||:..::||..:..|.:|.:.:|:|||.||:..|:.||.|..
Zfish   418 SFGVLLTEIVTYGRIPYPGMTNPEVIANLERGYRMPCPDNCPEALYNVMKHCWTENPDNRPTFEF 482

  Fly   773 LMDQL 777
            |...|
Zfish   483 LRSVL 487

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 18/53 (34%)
SH2_Tec_family 403..505 CDD:198188 28/105 (27%)
PTKc_Tec_like 521..778 CDD:173637 120/257 (47%)
lckNP_001001596.1 SH3_Lck 57..111 CDD:212938 18/55 (33%)
SH2_Src_Lck 116..216 CDD:198225 27/100 (27%)
PTKc_Lck_Blk 230..493 CDD:270652 122/260 (47%)
Blue background indicates that the domain is not in the aligned region.

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