DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Btk29A and lck

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_001001596.1	Gene:	lck / 414333	ZFINID:	ZDB-GENE-040617-1	Length:	503	Species:	Danio rerio

Alignment Length:	460	Identity:	178/460 - (38%)
Similarity:	264/460 - (57%)	Gaps:	20/460 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 IPTPG----TPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDAL- 386
            ||.|.    .|:|...:|     ||||:|.:......||..||..:.:::|.....|:..:...
Zfish    39 IPYPSQYTPPPSSPLPEN-----LVVAIYKYDPAHSDDLGFEKGEKMKILDCDDPEWYMAESLFT 98

  Fly   387 GNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRA-ESLLKQGDKEGCFVVRKSSTK-GLYTLSLH 449
            |..||||.|:|  ..|..:|...|:..::||..| ..||..|:.:|.|::|:|.|: |.:::|:.
Zfish    99 GQRGYIPKNFV--AKLNSMETEPWFYKNLSRNDAMRQLLAPGNTQGSFLIRESETQPGSFSISVR 161

  Fly   450 TKVPQSH--VKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTA 512
            ...|...  :|||.|:......:|::.|....::.:|:.::...:.||..|| ..||....|...
Zfish   162 DLDPMQGDIIKHYRIRNMDAGGFYITNKISFNSLSELVKHYSREADGLCTRL-VKPCQTRAPQKP 225

  Fly   513 GLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQ 577
            .. .|:||:....|.|...||.||||.|..|.:..:...|:|.:|.||||...|:.||.:|..||
Zfish   226 WW-QDEWEVPRESLKLERRLGQGQFGEVWMGLYNNNRQVAIKSLKPGTMSISAFLAEANLMKSLQ 289

  Fly   578 HPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHN 642
            ||.||:|:.|.:: .||||:||||::|||:::|:..|.:.| .:..|:||..||::||.|:|:.|
Zfish   290 HPRLVRLFAVVTQ-EPIYIITEYMENGSLVDFLKTPEGSDI-PINTLIDMAAQVAEGMAYVEQKN 352

  Fly   643 YIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVW 707
            ||||||.|.|.||..|...|:|||||||.:.:::||:..|.||||||..||.:||..||.|||||
Zfish   353 YIHRDLRAANILVSHELTCKIADFGLARLIKNNEYTAREGAKFPIKWTAPEAINYGTFSIKSDVW 417

  Fly   708 AYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRV 772
            ::|||:.||.|.|::||..:.|.||:..::||..:..|.:|.:.:|:|||.||:..|:.||.|..
Zfish   418 SFGVLLTEIVTYGRIPYPGMTNPEVIANLERGYRMPCPDNCPEALYNVMKHCWTENPDNRPTFEF 482

  Fly   773 LMDQL 777
            |...|
Zfish   483 LRSVL 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	18/53 (34%)
		SH2_Tec_family	403..505	CDD:198188	28/105 (27%)
		PTKc_Tec_like	521..778	CDD:173637	120/257 (47%)
		Pkinase_Tyr	526..777	CDD:285015	119/250 (48%)
lck	NP_001001596.1	SH3_Lck	57..111	CDD:212938	18/55 (33%)
		SH2_Src_Lck	116..216	CDD:198225	27/100 (27%)
		PTKc_Lck_Blk	230..493	CDD:270652	122/260 (47%)
		Pkinase_Tyr	238..487	CDD:285015	119/250 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920