Protein Alignment Btk and Csk

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Alignment Length: 938
• Identity: 251/938 - (26%)
• Similarity: 356/938 - (37%)
• Gaps: 258/938 - (27%)

  Fly    14 SIKSSSS----------LRSSSKSFQ---AKMDLM--SERLYDVVKSGSMVKRAQNKKRFTPVNY 63
            |.|..||          ||.:.:.||   ||.:|.  .:|.....:..:.....|..:...|:..
  Fly   197 SAKHESSPPIDARLLNFLRCAHRKFQASKAKTELQQTKDRFLGNSRERTSKNGQQTSRSLPPIAS 261

  Fly    64 KHRWF--ELTKRTFSYFDVEN-----VERRRERGRIHLKGVRLVEEATVSGEGGDPFAPDGYPF- 120
            ...||  |...|..|:...:.     .|..:|:..|..|         .||||      |....
  Fly   262 SEEWFDEEAQARKTSHEKSQKPKPKPEENHKEKEAISRK---------ASGEG------DLITVE 311

  Fly   121 --------QVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSEKERSE-WI 176
                    |........:.|||.....||..:   :.|...|.:.|..|:...|.:.....: |
  Fly   312 IKQGLLRKQTATTTTGQAMNSHATATQNGQTT---VVGHHRGFSQPSVTVAAAAATGSTAGDPW- 372

  Fly   177 RAIRQVCEDSNTPKSYRYH-------PGLWSGKKWSCCKGLSRTTFGCRAAA------------- 221
              ..|.......|.:...|       |....|      .|.|.|..|....|
  Fly   373 --FLQTTGHQMPPTAPLRHNKRPAPQPNAVLG------AGSSGTAPGSAVGAVLLHQQQLSQSQP 429

  Fly   222 ------------HWREANNNPSNG--------SSPAQNSTRSISPNSS--------------TTN 252
                        |.||.|.:|...        ||.|.||...||..|:              |||
  Fly   430 HIVPPSIPPHHHHHRENNVHPIQAGAAAALHLSSHALNSHNLISSASNHSPKSPSQTQQQQQTTN 494

  Fly   253 SQ----------------------FSLQHNSSGSLGGGVG----------------------GGL 273
            .|                      .::|...|.|:.|...                      ||.
  Fly   495 QQQQQQQQQASHSILSTFAPAPTVAAVQPAGSQSVAGTAAAVAAVAQQQQQQHLQLLANCPPGGA 559

  Fly   274 G------GGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLL-------DANMPG 325
            |      ....:|:.|        ...:|.|:|...:..|     :|:..||       .|:.|.
  Fly   560 GLMSSSLNAAQMGMHG--------AERALPPKSLALSGSQ-----HGSNMLLHTAPQPPQASQPA 611

  Fly   326 GIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVG 390
            .:  .|...|.:...|      .:|:.|. |.|.......||        ...|     :.|:..
  Fly   612 AV--VGVSGSGSAGMS------TSLHSFD-INGVTAGSGVNA--------SSAW-----SSGSTT 654

  Fly   391 YIPSNYVKPKALL---GLERYE-------WYVGDMSRQRAESLLKQGDKEGCFVVRKSST-KGLY 444
            .:....:.|.||.   |..|.|       |:.|.::|..||.|| |..::|.|:||:|:. .|.|
  Fly   655 AMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLL-QPREDGLFLVRESTNFPGDY 718

  Fly   445 TLSLHTKVPQSHVKHYHIKQNARCEYYLSEK------HCCETIPDLINYHRHNSGGLACRLKSSP 503
            ||.:   ..||.|:||.:|       ||..|      ...|.:..|:.::..::.||..:|  ..
  Fly   719 TLCV---CFQSKVEHYRVK-------YLENKLTIDDEEYFENLGQLVAHYEADADGLCTQL--IK 771

  Fly   504 CDRPVPPTAGLSH---------DK-WEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMK- 557
            |    .|..|...         || |.|...||.|.|.:|.|:||.|..|..|.. ..||||:|
  Fly   772 C----LPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNE-KVAVKMLKD 831

  Fly   558 EGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMG 622
            ||.:.:  |:.||.|||.|:|.|||:..|:....:.:|:|||||..|||::|||...:..|....
  Fly   832 EGAVQK--FLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKD 894

  Fly   623 LLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPI 687
            .:: .....:.||.|||....:||||||||.|:..:.|.||:||||||   ::.|....| |.||
  Fly   895 QII-FAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR---EECYNLDVG-KLPI 954

  Fly   688 KWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEI 752
            ||..||.|...|||:|||:|::|:|:|||::.|::||.|:...:||:.|:.|..:|.|:.|..||
  Fly   955 KWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEI 1019

  Fly   753 YDVMKLCWSHGPEERPAFRVLMDQLALV 780
            |::|:..|...|.:||.|..|..:|.|:
  Fly  1020 YEMMRQAWDLNPAKRPTFAELKVKLQLL 1047

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	38/226 (17%)
		SH3_Tec_like	346..399	CDD:212702	8/52 (15%)
		SH2_Tec_family	403..505	CDD:198188	34/118 (29%)
		PTKc_Tec_like	521..778	CDD:173637	110/257 (43%)
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	33/113 (29%)
		PTKc_Csk_like	793..1047	CDD:270635	112/261 (43%)