Protein Alignment Btk and FER

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Alignment Length: 629
• Identity: 178/629 - (28%)
• Similarity: 285/629 - (45%)
• Gaps: 146/629 - (23%)

  Fly   227 NNNPSNGSSPAQNS-----------TRSISPNSSTTNSQ-------------------------- 254
            |||..|.||.:.:|           |.:|:..::||.|:
  Fly   764 NNNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSK 828

  Fly   255 ---FSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTP-TSLQPQSSLTTFKQSPTLLNGN 315
               |.|:.:....                         .||. ..:.|..|:..|.:...:....
  Fly   829 LLNFQLKRSKPCK-------------------------QCTKRRRIHPSKSVFDFAKEFEVEQPA 868

  Fly   316 GTLLD---ANMPGGIPTPGTPN---SKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDD 374
            |:..|   .|.|.....|..|:   |..||           :||::..|   .|::|::.::.:|
  Fly   869 GSAADEQFCNCPPAGQKPVKPSVQISGHKD-----------HPFESSSG---ELDENSDRDIDND 919

  Fly   375 SQEHWWKVKDALGNVGY---IPS-------NYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDK 429
            .:|......|.|....:   :||       :..:|     |...||:.|.:.|:....||   :.
  Fly   920 EEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRP-----LYEEEWFHGVLPREEVVRLL---NN 976

  Fly   430 EGCFVVRKS--STKGLYTLSL----HTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYH 488
            :|.|:||::  :.:....||:    |        ||:.::......:.. |.....:|.:||.:.
  Fly   977 DGDFLVRETIRNEESQIVLSVCWNGH--------KHFIVQTTGEGNFRF-EGPPFASIQELIMHQ 1032

  Fly   489 RHNSGGLACRLKSSP-CDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGS-IDT 551
            .|:.  |...:||.. ..|||      ..::||:...:::|:|.:|.|.||.|.:.|.:.: :|.
  Fly  1033 YHSE--LPVTVKSGAILRRPV------CRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDV 1089

  Fly   552 AVKMMKEGTMSEDD---FIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRH 613
            |||..:. |:.::.   |::|.:::.:..|||:|:|.|:|.:.:||.||.|.:..||||.|||::
  Fly  1090 AVKTCRM-TLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKN 1153

  Fly   614 EK--TLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQ 676
            ..  |....||    ||...:.||.|||..|.||||||||||||..|:.||::|||::|.  :::
  Fly  1154 SNGLTTRQQMG----MCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEE 1212

  Fly   677 YTSSGGTK-FPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGI 740
            |..|.|.| .|:||..||.||:.:::|..|||:||:||||||:.|..||..:.|:...||:..|.
  Fly  1213 YIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGY 1277

  Fly   741 ILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQTL 784
            .:..|||..:|:|.:|..||:...|.||.|    |::..|...|
  Fly  1278 RMPTPKSTPEEMYRLMLQCWAADAESRPHF----DEIYNVVDAL 1317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	11/62 (18%)
		SH2_Tec_family	403..505	CDD:198188	24/108 (22%)
		PTKc_Tec_like	521..778	CDD:173637	107/263 (41%)
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	23/104 (22%)
		PTKc_Fes_like	1067..1315	CDD:270637	107/258 (41%)