Protein Alignment Btk and syk

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_005155595.1
• Gene: syk / 405769
• ZFINID: ZDB-GENE-040702-3
• Length: 608
• Species: Danio rerio
• Alignment Length: 597
• Identity: 164/597 - (27%)
• Similarity: 272/597 - (45%)
• Gaps: 127/597 - (21%)

  Fly   284 GGGGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLL----------------DANMPGGIPTPGT 332
            ||.|.|            |...:||.:.|.|....|                |.....|..:..|
Zfish    27 GGSGDG------------LYLLRQSRSFLGGYALSLSYGRQFYHYTIERELNDTYAIAGGKSHRT 79

  Fly   333 P----NSKAKDNSHFVKLVVALYPFKAIEGGDLSLE--KNAEYEVIDDSQEHWWKVKDALGNVGY 391
            |    |..::::...:.|:..  ||....|.:..:.  ::.:.::|....|..|.:|.:..:...
Zfish    80 PIDVINYHSQESDGLICLLKK--PFHRPRGTEPKVGPFEDLKEQLIRQYVEQTWNLKGSALDQAI 142

  Fly   392 IPSNYVKPK-----ALLGLERYEWYVGDMSRQRAE-SLLKQGDKEGCFVVRKSSTKG---LYTLS 447
            |..   :|:     |....|:..|:.|.:.|:.:| .||......|.|::|:....|   .|.|.
Zfish   143 ISQ---RPQLEKLIATTAHEKMPWFHGKIDREDSELRLLNTSRVNGKFLIRQRENSGRNESYALC 204

  Fly   448 LHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYH------------------RHNS-- 492
            |   :..:.|.||.|.::...:..:.:....:|:..|:.::                  .|:|
Zfish   205 L---LHNNQVMHYRIDKDRAGKLSIPDGKKFDTLWQLVEHYSYKPDGLLRVLTETCPRPSHHSER 266

  Fly   493 ---GGLACRLKSSPCDRP------------VPPTAGLSHDKW-----EIHPMELMLME------- 530
               ||:..||||....:|            :.|.....:.|.     ...||:..:.|
Zfish   267 GATGGIISRLKSYSFPKPGQKKGSAENPYKITPNGKDDYSKQGNFLDSAMPMDTQVYESPYADPD 331

  Fly   531 -----------------ELGSGQFGVVRRGKW---RGSIDTAVKMMK---EGTMSEDDFIEEAKV 572
                             |||||.||.|.||.:   :.....|||::|   :....:|:.:.||.|
Zfish   332 ELRSTKVNRSDLTLEDGELGSGNFGTVLRGVYQMKKTQKVVAVKILKNDDDNAAVKDEMLREANV 396

  Fly   573 MTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTY 637
            |.:|.:|.:|::.|:|.... :.:|.|..:.|.|..:|::::...:.|   |.::..|||.||.|
Zfish   397 MQQLDNPYIVRMIGICEAEN-LMLVMELAELGPLHKFLQKNKHITVKN---LTELVHQVSMGMKY 457

  Fly   638 LERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQ--YTSSGGTKFPIKWAPPEVLNYTRF 700
            ||.||::||||||||.|:.:::..|::||||::.:.:|:  |.:.|..|:|:||..||.:||.:|
Zfish   458 LEEHNFVHRDLAARNVLLVTQHYAKISDFGLSKALTEDENYYKAKGHGKWPLKWYAPECMNYLKF 522

  Fly   701 SSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPE 765
            |||||||::||||||.|:.|:.||..:|..||::.::.|..:..|..|..|:||:||.||::.|:
Zfish   523 SSKSDVWSFGVLMWEAFSYGQKPYKGMKGNEVIQMIENGQRMSAPPDCPPEMYDLMKKCWTYKPD 587

  Fly   766 ERPAFRVLMDQL 777
            |||.|.|:..:|
Zfish   588 ERPGFSVVEPRL 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	9/54 (17%)
		SH2_Tec_family	403..505	CDD:198188	28/128 (22%)
		PTKc_Tec_like	521..778	CDD:173637	107/289 (37%)
syk	XP_005155595.1	SH2_N-SH2_Zap70_Syk_like	8..111	CDD:198191	19/97 (20%)
		SH2_C-SH2_Syk_like	159..260	CDD:198264	20/103 (19%)
		PTKc_Syk	348..604	CDD:133247	104/256 (41%)