Protein Alignment Btk29A and LCK

DIOPT Version :9

• Sequence 1: NP_001097121.1
• Gene: Btk29A / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_024302814.1
• Gene: LCK / 3932
• HGNCID: 6524
• Length: 567
• Species: Homo sapiens
• Alignment Length: 575
• Identity: 211/575 - (36%)
• Similarity: 304/575 - (52%)
• Gaps: 96/575 - (16%)

  Fly   225 EANNNPSNGSSPAQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGG 289
            |.:|.|   :||.|...|           |..|:..:.|||..|
Human    52 EGSNPP---ASPLQGDPR-----------QQGLKDKACGSLAVG--------------------- 81

  Fly   290 SCTPTSLQPQSSLTTFKQSPT-LLNGNGTLLDANM-PGGIPTPG---------TPNSKAKDNSHF 343
                           |..||| .|.|...|:...: ||.:|.|.         |.|
Human    82 ---------------FHLSPTYFLPGLAFLVPHPVTPGFLPIPARFSLMPLVFTDN--------- 122

  Fly   344 VKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKD-ALGNVGYIPSNYVKPKALLGLER 407
              ||:||:.::....|||..||..:..:::.|.| |||.:. ..|..|:||.|:| .|| ..||.
Human   123 --LVIALHSYEPSHDGDLGFEKGEQLRILEQSGE-WWKAQSLTTGQEGFIPFNFV-AKA-NSLEP 182

  Fly   408 YEWYVGDMSRQRAE-SLLKQGDKEGCFVVRKS-STKGLYTLSLHTKVPQSH---VKHYHIKQNAR 467
            ..|:..::||:.|| .||..|:..|.|::|:| ||.|.::||:. ...|:.   ||||.|:....
Human   183 EPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVR-DFDQNQGEVVKHYKIRNLDN 246

  Fly   468 CEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPC--DRPVPPTAGLSHDKWEIHPMELMLME 530
            ..:|:|.:.....:.:|:.::.:.|.||..|| |.||  .:|..|   ...|:||:....|.|:|
Human   247 GGFYISPRITFPGLHELVRHYTNASDGLCTRL-SRPCQTQKPQKP---WWEDEWEVPRETLKLVE 307

  Fly   531 ELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIY 595
            .||:||||.|..|.:.|....|||.:|:|:||.|.|:.||.:|.:|||..||:||.|.:: .|||
Human   308 RLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQ-EPIY 371

  Fly   596 IVTEYMKHGSLLNYLRRHEKTLIG---NMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGS 657
            |:||||::|||:::|    ||..|   .:..||||..|:::||.::|..|||||||.|.|.||..
Human   372 IITEYMENGSLVDFL----KTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD 432

  Fly   658 ENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKM 722
            ....|:|||||||.:.|::||:..|.||||||..||.:||..|:.|||||::|:|:.||.|.|::
Human   433 TLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRI 497

  Fly   723 PYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            ||..:.|.||::.::||..:.:|.:|.:|:|.:|:|||...||:||.|..|...|
Human   498 PYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVL 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	20/53 (38%)
		SH2_Tec_family	403..505	CDD:198188	36/108 (33%)
		PTKc_Tec_like	521..778	CDD:173637	122/260 (47%)
		Pkinase_Tyr	526..777	CDD:285015	121/253 (48%)
LCK	XP_024302814.1	SH3_Lck	123..176	CDD:212938	20/54 (37%)
		SH2_Src_Lck	181..281	CDD:198225	33/101 (33%)
		PTKc_Lck_Blk	295..558	CDD:270652	124/263 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820