DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and Egfr

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster


Alignment Length:312 Identity:108/312 - (34%)
Similarity:170/312 - (54%) Gaps:30/312 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   497 CRLKSSPCDRPVPPTAGLS--HDKWEIHP-------MELMLMEE--------LGSGQFGVVRRGK 544
            ||.|.......|..|..||  .|...:.|       .:|.::::        ||.|.||.|.:|.
  Fly   892 CRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGV 956

  Fly   545 W-----RGSIDTAVK--MMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMK 602
            |     ...|..|:|  :...|..|.::|:.||.:|..::|.||::|..||...: :.::|:.|.
  Fly   957 WVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQ-MMLITQLMP 1020

  Fly   603 HGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFG 667
            .|.||:|: |:.:..||:.. ||:...|::|||:|||....:||||||||.||.:.::||:.|||
  Fly  1021 LGCLLDYV-RNNRDKIGSKA-LLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFG 1083

  Fly   668 LARYVLDD--QYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNT 730
            ||:.:..|  :|.::|| |.||||...|.:....|:|||||||:||.:||:.|.|:.|:..:...
  Fly  1084 LAKLLSSDSNEYKAAGG-KMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAK 1147

  Fly   731 EVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQ 782
            ::.:.::.|:.||:|:.|:.:||..:..||......||.|:.|....|..|:
  Fly  1148 DIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFAR 1199

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702
SH2_Tec_family 403..505 CDD:198188 3/7 (43%)
PTKc_Tec_like 521..778 CDD:173637 98/280 (35%)
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032
Furin-like 253..401 CDD:395614
Recep_L_domain 419..547 CDD:460032
GF_recep_IV 572..684 CDD:464344
FU 662..716 CDD:214589
GF_recep_IV 740..>834 CDD:464344
PTKc_EGFR_like 930..1208 CDD:270648 99/274 (36%)
Blue background indicates that the domain is not in the aligned region.

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