DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and fyna

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_001315092.1	Gene:	fyna / 373872	ZFINID:	ZDB-GENE-030903-5	Length:	537	Species:	Danio rerio

Alignment Length:	464	Identity:	201/464 - (43%)
Similarity:	284/464 - (61%)	Gaps:	27/464 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 GGIPT---PGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKD-A 385
            ||:.:   .||..|:....   |.|.||||.::|....|||..|..::::::.::..||:.:. .
Zfish    65 GGVNSSSHSGTLRSRGGTG---VTLFVALYDYEARSEDDLSFRKGEKFQILNSTEGDWWEARSLT 126

  Fly   386 LGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAE-SLLKQGDKEGCFVVRKS-STKGLYTLSL 448
            .|..||||||||.|  :..::..:||.|.:.|:.|| .||..|:..|.|::|:| :|||.|:||:
Zfish   127 TGGTGYIPSNYVAP--VDSIQAEDWYFGKLGRKDAERQLLSNGNPRGTFLIRESETTKGAYSLSI 189

  Fly   449 H--TKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPT 511
            .  .:....|||||.|::.....||::.:...||:..|::::...:.||.||| ..||.:.:|..
Zfish   190 QDWDETKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVHHYSARAAGLCCRL-IVPCHKGMPRL 253

  Fly   512 AGLS---HDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVM 573
            |.||   .|.|||....|.|::.||:||||.|..|.|.|:...|||.:|.||||.:.|:|||::|
Zfish   254 ADLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAVKTLKPGTMSPESFLEEAQIM 318

  Fly   574 TKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGL----LLDMCIQVSKG 634
            .||:|..|||||.|.|: .|||||||||..||||::|:..|     ..||    |:||..||:.|
Zfish   319 KKLRHDKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKDGE-----GRGLKLPNLVDMAAQVAAG 377

  Fly   635 MTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTR 699
            |.|:||.|||||||.:.|.|||...|.|:|||||||.:.|::||:..|.||||||..||...|.|
Zfish   378 MAYIERMNYIHRDLRSANILVGDSLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 442

  Fly   700 FSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGP 764
            |:.|||||::|:|:.|:.|.|::||..:.|.||:|:|:||..:..|:.|...::::|..||...|
Zfish   443 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPSSLHELMLQCWKRDP 507

  Fly   765 EERPAFRVL 773
            ||||.|..|
Zfish   508 EERPTFEYL 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	21/53 (40%)
		SH2_Tec_family	403..505	CDD:198188	36/105 (34%)
		PTKc_Tec_like	521..778	CDD:173637	129/257 (50%)
		Pkinase_Tyr	526..777	CDD:285015	128/252 (51%)
fyna	NP_001315092.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	13..34
		SH3_Fyn_Yrk	85..140	CDD:212939	21/54 (39%)
		SH2_Src_Fyn_isoform_a_like	145..245	CDD:198281	35/100 (35%)
		PTKc_Fyn	261..534	CDD:270655	132/262 (50%)
		Pkinase_Tyr	271..520	CDD:285015	128/252 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820