Protein Alignment Btk and JAK3

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_000206.2
• Gene: JAK3 / 3718
• HGNCID: 6193
• Length: 1124
• Species: Homo sapiens
• Alignment Length: 440
• Identity: 130/440 - (29%)
• Similarity: 196/440 - (44%)
• Gaps: 71/440 - (16%)

  Fly   397 VKPKALLGLE----RYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHV 457
            |.| |:|.||    |..|...:..|: |::|..:.||.|..........|: |:.:....|...:
Human   674 VSP-AVLSLEMLTDRIPWVAPECLRE-AQTLSLEADKWGFGATVWEVFSGV-TMPISALDPAKKL 735

  Fly   458 KHYHIKQNARC----EYYLSEKHCC-----------ETIPDL-----INYHRHNSGGLACRLKSS 502
            :.|..:|....    |..|..:.|.           ..|.||     .:|          .|.|.
Human   736 QFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDY----------ELLSD 790

  Fly   503 PCDRPVPPTAGL--------SHDKWEIHPMELMLMEELGSGQFGVVR------RGKWRGSIDTAV 553
            |....:.|..||        ..|........|..:.:||.|.||.|.      .|...|::....
Human   791 PTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVK 855

  Fly   554 KMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVC--SKHRPIYIVTEYMKHGSLLNYLRRHEKT 616
            ::...|...:.||..|.:::..|....:|:..||.  ...:.:.:|.||:..|.|.::|:||...
Human   856 QLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRAR 920

  Fly   617 LIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYV-LD-DQYTS 679
            |..:..||...  |:.|||.||.....:||||||||.||.||..||:||||||:.: || |.|..
Human   921 LDASRLLLYSS--QICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVV 983

  Fly   680 SGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFT-CGK-----MPYGRLKNTE------- 731
            ....:.||.|..||.|:...||.:||||::||:::|:|| |.|     ..:.|:...|
Human   984 REPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALC 1048

  Fly   732 -VVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALV 780
             ::|.::.|..|..|.:|..|::::|||||:..|::||:|..|..||.::
Human  1049 RLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDML 1098

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	1/1 (100%)
		SH2_Tec_family	403..505	CDD:198188	26/125 (21%)
		PTKc_Tec_like	521..778	CDD:173637	96/280 (34%)
JAK3	NP_000206.2	Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250	1..223
		FERM_F1	26..112	CDD:465733
		FERM_B-lobe	126..245	CDD:481193
		PH-like	250..362	CDD:473070
		SH2_Jak3	362..458	CDD:198243
		PTK_Jak3_rpt1	521..778	CDD:271110	24/106 (23%)
		PTKc_Jak3_rpt2	817..1099	CDD:270665	97/284 (34%)