DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk29A and JAK1

DIOPT Version :9

Sequence 1:NP_001097121.1 Gene:Btk29A / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_001307852.1 Gene:JAK1 / 3716 HGNCID:6190 Length:1154 Species:Homo sapiens


Alignment Length:985 Identity:211/985 - (21%)
Similarity:334/985 - (33%) Gaps:336/985 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 HVNGSIKSSSSLRSSSKS----FQAKMDLMSERLYDVVKSGSM------------VKRAQNKKRF 58
            |....|..:|.|..||::    |.:. |..:...|:|:.:|::            |::.:||.:.
Human   280 HYGAEIFETSMLLISSENEMNWFHSN-DGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKR 343

  Fly    59 TPVNYKHRWFELTKR------TFSYF-DVENVERRRERGRIHLKGVRLVEEATVSGEGGDPFAPD 116
            ..:..||:..|...:      .|||| ::.::..:.....|:.:..:.:|....|.|....|.  
Human   344 KKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFV-- 406

  Fly   117 GYPFQVGYCEISASANS------------HQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSE 169
              ....||..::|.|:.            |.::||..|               |..|.|.|....
Human   407 --SLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHG---------------PICTEYAINKLR 454

  Fly   170 KERSEWIRAIRQVCEDSNTPKSYRYHPGLWSGKKWSC-----------CKGLSRTTFGCRAAAHW 223
            :|.||                     .|::. .:|||           |...|....|  |...:
Human   455 QEGSE---------------------EGMYV-LRWSCTDFDNILMTVTCFEKSEQVQG--AQKQF 495

  Fly   224 REANNNPSNGSSPAQNSTRSISPNSS------------TTNSQFSLQHNSSGSLGGGVGGGLGGG 276
            :........|......|.||. |:..            |.|..|.|:.                 
Human   496 KNFQIEVQKGRYSLHGSDRSF-PSLGDLMSHLKKQILRTDNISFMLKR----------------- 542

  Fly   277 GSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQS-------------------PTLLNG-------- 314
                         .|.|...:..:.|...|::                   ..|:.|        
Human   543 -------------CCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTR 594

  Fly   315 ----NGTLLDANMPGGIPTPGTPNS-------KAKDNSH------FV-----------KLVVALY 351
                :|||:|..     ...||...       |..|.||      |.           |.:|.||
Human   595 THIYSGTLMDYK-----DDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLY 654

  Fly   352 PF-----------KAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDA---------LGNVGYIPSNY 396
            ..           :.:|||.|.|..:.:.:|:...    ||.|.|         |.:...:..|.
Human   655 GVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTP----WKFKVAKQLASALSYLEDKDLVHGNV 715

  Fly   397 VKPKALLGLERYEWYVGD-------------MSRQR---------------AESLLKQGDKEGCF 433
            .....||..|..:...|.             :|||.               :::|....||    
Human   716 CTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADK---- 776

  Fly   434 VVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCE---YYLSEKHC------CETIPDL----I 485
               .|....|:.:..:.::|        :|.....|   :|  |..|      |:.:.||    :
Human   777 ---WSFGTTLWEICYNGEIP--------LKDKTLIEKERFY--ESRCRPVTPSCKELADLMTRCM 828

  Fly   486 NYHRHNSGGLACRLKSSPCDRPV---------------PPTAGLSHDKWEIHPME-----LMLME 530
            ||              .|..||.               |..........|:.|..     |..:.
Human   829 NY--------------DPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIR 879

  Fly   531 ELGSGQFGVVRRGKWRGSID-----TAVKMMK--EGTMSEDDFIEEAKVMTKLQHPNLVQLYGVC 588
            :||.|.||.|...::....|     .|||.:|  .|.....|..:|.:::..|.|.|:|:..|:|
Human   880 DLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGIC 944

  Fly   589 SKH--RPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAAR 651
            ::.  ..|.::.|::..|||..||.:::..:  |:...|...:|:.|||.||....|:|||||||
Human   945 TEDGGNGIKLIMEFLPSGSLKEYLPKNKNKI--NLKQQLKYAVQICKGMDYLGSRQYVHRDLAAR 1007

  Fly   652 NCLVGSENVVKVADFGLARYVLDDQ--YTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMW 714
            |.||.||:.||:.||||.:.:..|:  ||.......|:.|..||.|..::|...||||::||.:.
Human  1008 NVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLH 1072

  Fly   715 EIFT-CG----------KM---PYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPE 765
            |:.| |.          ||   .:|::..|.:|..::.|..|..|.:|..|:|.:|:.||...|.
Human  1073 ELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPS 1137

  Fly   766 ERPAFRVLMD 775
            .|.:|:.|::
Human  1138 NRTSFQNLIE 1147

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Btk29ANP_001097121.1 PH_Btk 44..222 CDD:269944 39/219 (18%)
SH3_Tec_like 346..399 CDD:212702 15/72 (21%)
SH2_Tec_family 403..505 CDD:198188 23/142 (16%)
PTKc_Tec_like 521..778 CDD:173637 92/285 (32%)
Pkinase_Tyr 526..777 CDD:285015 91/275 (33%)
JAK1NP_001307852.1 B41 37..286 CDD:214604 1/5 (20%)
FERM_C_JAK1 282..426 CDD:275412 29/148 (20%)
SH2 426..527 CDD:301589 24/140 (17%)
PTK_Jak1_rpt1 583..846 CDD:270662 55/302 (18%)
Pkinase_Tyr 583..845 CDD:285015 55/301 (18%)
PTKc_Jak1_rpt2 870..1153 CDD:173644 91/280 (33%)
TyrKc 875..1149 CDD:197581 91/275 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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