DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Btk29A and ITK

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_005537.3	Gene:	ITK / 3702	HGNCID:	6171	Length:	620	Species:	Homo sapiens

Alignment Length:	757	Identity:	287/757 - (37%)
Similarity:	400/757 - (52%)	Gaps:	170/757 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 MVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVRLVEEATVSGEGGDP 112
            ::|::|.|:|.:|.|:|.|:|.|||.:.:||:..:.::|..:|.|.|..::.||  .|..:...|
Human    11 LIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVE--IVKSDISIP 73

  Fly   113 FAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSEKERSEWIR 177
             ....|||||.:                                 ..|.|||.|...:.|..|:.
Human    74 -CHYKYPFQVVH---------------------------------DNYLLYVFAPDRESRQRWVL 104

  Fly   178 AIRQVCEDSNT--PKSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREANNNPSNGSSPAQNS 240
            |:::...::|:  ||   |||..|...||.||..|.:...||   |.:           .|.:|:
Human   105 ALKEETRNNNSLVPK---YHPNFWMDGKWRCCSQLEKLATGC---AQY-----------DPTKNA 152

  Fly   241 TRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSSLTTF 305
            ::.
Human   153 SKK-------------------------------------------------------------- 155

  Fly   306 KQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFV-----KLVVALYPFKAIEGGDLSLEK 365
                                  |.|.||    :||...:     .:|:|||.::..:..:|:|.:
Human   156 ----------------------PLPPTP----EDNRRPLWEPEETVVIALYDYQTNDPQELALRR 194

  Fly   366 NAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKE 430
            |.||.::|.|:.|||:|:|..|:.||:||:|:..|:...||.||||...:||.:||.||....||
Human   195 NEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKE 259

  Fly   431 GCFVVRKSSTKGLYTLSLHTKVPQSH----VKHYHIKQ---NARCEYYLSEKHCCETIPDLINYH 488
            |.|:||.|.|.|.||:|:.||...|.    :||||||:   |.: .||::||:..::||.|||||
Human   260 GAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPK-RYYVAEKYVFDSIPLLINYH 323

  Fly   489 RHNSGGLACRLKSSPC--DRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDT 551
            :||.|||..||:...|  .:..|.||||.:.||.|.|.||..::|:||||||:|..|.|......
Human   324 QHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKV 388

  Fly   552 AVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHE-- 614
            |:|.::||.|||:||||||:||.||.||.||||||||.:..||.:|.|:|:||.|.:|||...
Human   389 AIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGL 453

  Fly   615 ---KTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQ 676
               :||:|       ||:.|.:||.|||....|||||||||||||...|:||:|||:.|:|||||
Human   454 FAAETLLG-------MCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQ 511

  Fly   677 YTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGII 741
            ||||.|||||:|||.|||.:::|:|||||||::||||||:|:.||:||....|:||||.:..|..
Human   512 YTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFR 576

  Fly   742 LEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQT 783
            |.||:..:..:|.:|..||...||:||||..|:.|||.:|::
Human   577 LYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAES 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944	49/175 (28%)
		SH3_Tec_like	346..399	CDD:212702	22/52 (42%)
		SH2_Tec_family	403..505	CDD:198188	53/110 (48%)
		PTKc_Tec_like	521..778	CDD:173637	143/261 (55%)
		Pkinase_Tyr	526..777	CDD:285015	139/255 (55%)
ITK	NP_005537.3	PH_Btk	7..148	CDD:269944	50/189 (26%)
		SH3_ITK	174..229	CDD:212841	22/54 (41%)
		SH2_Tec_Itk	232..340	CDD:198259	52/108 (48%)
		PTKc_Itk	358..613	CDD:133243	143/261 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	316	1.000	Domainoid score	I1267
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	572	1.000	Inparanoid score	I1050
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52659
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm42091
orthoMCL	1	0.900	-	-		OOG6_102306
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X592
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.830