Protein Alignment Btk and drk

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_476858.1
• Gene: drk / 36497
• FlyBaseID: FBgn0004638
• Length: 211
• Species: Drosophila melanogaster
• Alignment Length: 218
• Identity: 59/218 - (27%)
• Similarity: 102/218 - (46%)
• Gaps: 43/218 - (19%)

  Fly   348 VALYPFKAIEGGDLSLEKNAEYEVI---DDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYE 409
            :|.:.|.|....:||..|....:::   |||  :|::. :..|..|.|||||::      ::.::
  Fly     4 IAKHDFSATADDELSFRKTQILKILNMEDDS--NWYRA-ELDGKEGLIPSNYIE------MKNHD 59

  Fly   410 WYVGDMSRQRAESLLKQGDKEGCFVVRKS-STKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLS 473
            ||.|.::|..||.|| ....||.|::|.| |:.|.::||:  |.|.. |:|:.:.::|:.:::|.
  Fly    60 WYYGRITRADAEKLL-SNKHEGAFLIRISESSPGDFSLSV--KCPDG-VQHFKVLRDAQSKFFLW 120

  Fly   474 EKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFG 538
            ... ..::.:|:.|||..|...:..:|.    |.:.|...|....::..|.|        ||:..
  Fly   121 VVK-FNSLNELVEYHRTASVSRSQDVKL----RDMIPEEMLVQALYDFVPQE--------SGELD 172

  Fly   539 VVRRGK------------WRGSI 549
             .|||.            |.|.|
  Fly   173 -FRRGDVITVTDRSDENWWNGEI 194

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	17/53 (32%)
		SH2_Tec_family	403..505	CDD:198188	29/102 (28%)
		PTKc_Tec_like	521..778	CDD:173637	10/41 (24%)
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	16/51 (31%)
		SH2_Grb2_like	56..149	CDD:199828	29/101 (29%)
		SH3_GRB2_like_C	156..208	CDD:212739	11/48 (23%)