Protein Alignment Btk and Nrk

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_477255.1
• Gene: Nrk / 36445
• FlyBaseID: FBgn0020391
• Length: 724
• Species: Drosophila melanogaster
• Alignment Length: 537
• Identity: 148/537 - (27%)
• Similarity: 227/537 - (42%)
• Gaps: 107/537 - (19%)

  Fly   302 LTTFKQSPT---LLNGNGTLLDANMPGGIPTPGTPNSK---AKDNSHFVKLVVALYPFKAIEGGD 360
            ||..|:|..   ..||||......|  .:...|.|..:   ...:.||...:|.   .:.:||.:
  Fly   207 LTELKESEVSYDCRNGNGRFYMGTM--NVSKSGIPCQRWDTQYPHKHFQPPLVF---HQLLEGEN 266

  Fly   361 LSLEKNAEYE-------VIDDSQEHWWKVKDALGNVGYIP--SNYVKPKAL-----LGLERYEWY 411
            ..  :||..|       .:|:|..  |:..|       ||  .:||.|.|:     :.:|::  :
  Fly   267 YC--RNAGGEEPHPWCYTVDESVR--WQHCD-------IPMCPDYVDPNAVDLNTPIKMEKF--F 318

  Fly   412 VGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQ-----NARCEYY 471
            ...|                .|::.......:.||.|...:.....||....|     .|.|...
  Fly   319 TPSM----------------IFLLAGIGFVAIVTLHLMILLVYKLSKHKDYSQPAGAATAECSVS 367

  Fly   472 LSEKHCCETIPDLINYHRHNSGG-----------------------LACRLKSSPCD-RPVPPTA 512
            :.....|   ...:|..|...||                       :|....::..| :...|.|
  Fly   368 MRGGGDC---GGNLNTSRETLGGNGNTNTLAKWGTIRSTATIHSNCVALTTVTNVSDAKGTKPNA 429

  Fly   513 GLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSID------TAVKMMKE--GTMSEDDFIEE 569
            .|  :|.|....:::.:..||.|.||.|.:.:..|.:.      .||||:|:  ....:.||..|
  Fly   430 RL--EKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFERE 492

  Fly   570 AKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLR------RHEKTLIGNMGL----L 624
            |.::.:..|||:|:|.|||:..||:.::.|||..|.|..:||      .|:......:.|    |
  Fly   493 ACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQDRLQLNELHL 557

  Fly   625 LDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYV-LDDQYTSSGGTKFPIK 688
            |.|...::.||.||....::|||||.||||:.....||:|||||:..: |.|.|........||:
  Fly   558 LQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFIPIR 622

  Fly   689 WAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIY 753
            |.|.|.:.|.:||.:|||||||:.:||:|:....||..|.:.||::.::.|.:|..|.:....:|
  Fly   623 WMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTPLSVY 687

  Fly   754 DVMKLCWSHGPEERPAF 770
            .:|:.||:..|.|||.|
  Fly   688 ALMRRCWNRKPSERPGF 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	14/61 (23%)
		SH2_Tec_family	403..505	CDD:198188	17/129 (13%)
		PTKc_Tec_like	521..778	CDD:173637	96/269 (36%)
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:470581	2/4 (50%)
		KR	217..299	CDD:214527	21/97 (22%)
		PTKc_Musk	435..713	CDD:133181	97/270 (36%)