Protein Alignment Btk and Blk

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_006252250.1
• Gene: Blk / 364403
• RGDID: 1308859
• Length: 554
• Species: Rattus norvegicus
• Alignment Length: 617
• Identity: 209/617 - (33%)
• Similarity: 306/617 - (49%)
• Gaps: 111/617 - (17%)

  Fly   179 IRQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREANNNPSNGSSPA------ 237
            :|.:.|:.:|||.      ||....|                     ..::..:.|.|.
  Rat    16 LRPLAEEVSTPKR------LWRQLSW---------------------GRDSAESASMPCGLLRLF 53

  Fly   238 -----QNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQ 297
                 .:|.|.||..|   .|...::..:.|.:                           |..|.
  Rat    54 LRMGLLSSKRQISEKS---KSWSPVKARAQGKV---------------------------PPPLP 88

  Fly   298 PQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLS 362
            |   |..|...|                    |.:||....:...|   ||||:.:.|:...||.
  Rat    89 P---LVVFNHLP--------------------PPSPNQHPDEEERF---VVALFDYAAVNDRDLQ 127

  Fly   363 LEKNAEYEVIDDSQEHWWKVKDAL-GNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAE-SLLK 425
            :.|..:.:|:..:.: ||..:..: |..||:|||:|.|...|.:|:  |:...:||:.|| .||.
  Rat   128 VLKGEKLQVLKSTGD-WWLARSLVTGREGYVPSNFVAPVETLEVEK--WFFRTISRKDAERQLLA 189

  Fly   426 QGDKEGCFVVRKS-STKGLYTLSLHTKVPQSH-VKHYHIKQNARCEYYLSEKHCCETIPDLINYH 488
            ..:|.|.|::|:| |.||.::||:.....|.. ||||.|:......||:|.:....|:..|:.::
  Rat   190 PMNKAGSFLIRESESNKGAFSLSVKDVTSQGEMVKHYKIRSLDNGGYYISPRITFPTLQALVQHY 254

  Fly   489 RHNSGGLACRLKSSPCDRPVP--PTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDT 551
            .....|| |:..:.||..|.|  |.|   .|:|||....|.|:.:|||||||.|..|.::.::..
  Rat   255 SEKGDGL-CQKLTLPCVNPAPKNPWA---QDEWEIPRQSLKLVRKLGSGQFGEVWMGYYKNNMKV 315

  Fly   552 AVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKT 616
            |:|.:||||||.:.|:.||.||..|||..||:||.|.:: .|||||||||..|.||::|:..|.:
  Rat   316 AIKTLKEGTMSPEAFLGEANVMKTLQHERLVRLYAVVTR-EPIYIVTEYMARGCLLDFLKTDEGS 379

  Fly   617 LIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSG 681
            .: ::..|:||..||::||.|:||.|.|||||.|.|.||......|:||||||| ::|.:||:..
  Rat   380 RL-SLPRLIDMSAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLAR-IIDSEYTAQE 442

  Fly   682 GTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPK 746
            |.||||||..||.:::..|:.|:|||::|||:.||.|.|::||..:.|.||:..::.|..:..|:
  Rat   443 GAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGRVPYPGMSNPEVIRSLEHGYRMPCPE 507

  Fly   747 SCAKEIY-DVMKLCWSHGPEERPAFRVLMDQL 777
            :|..|:| ||:..||...|||||.|..|...|
  Rat   508 TCPPELYHDVITECWRGRPEERPTFEFLQSVL 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	8/42 (19%)
		SH3_Tec_like	346..399	CDD:212702	18/53 (34%)
		SH2_Tec_family	403..505	CDD:198188	34/104 (33%)
		PTKc_Tec_like	521..778	CDD:173637	121/258 (47%)
Blk	XP_006252250.1	SH3	111..164	CDD:473055	19/56 (34%)
		SH2	169..268	CDD:472789	32/101 (32%)
		Protein Kinases, catalytic domain	282..545	CDD:473864	123/261 (47%)