DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Btk29A and Itk

DIOPT Version :9

Sequence 1:NP_001097121.1 Gene:Btk29A / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_001102295.2 Gene:Itk / 363577 RGDID:1311618 Length:620 Species:Rattus norvegicus


Alignment Length:753 Identity:280/753 - (37%)
Similarity:394/753 - (52%) Gaps:164/753 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 MVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVRLVEEATVSGEGGDP 112
            ::|::|.|:|.:|.|:|.|:|.|||.:.:||:..:.::|..:|.|.|..::.||  .|..:...|
  Rat    11 LIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVE--IVKSDISIP 73

  Fly   113 FAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSEKERSEWIR 177
             ....|||||.:                                 ..|.|||.|...:.|..|:.
  Rat    74 -CHYKYPFQVMH---------------------------------DNYLLYVFAPDCESRQRWVL 104

  Fly   178 AIRQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREANNNPSNGSSPAQNSTR 242
            .:::...::|:..| :|||..|...:|.||..|.:...||..              ..|.:|:::
  Rat   105 TLKEETRNNNSLVS-KYHPNFWMDGRWRCCSQLEKLAVGCAP--------------YDPTKNASK 154

  Fly   243 SISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQ 307
            .                                                                
  Rat   155 K---------------------------------------------------------------- 155

  Fly   308 SPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVK-----LVVALYPFKAIEGGDLSLEKNA 367
                                |.|.||    :||....:     ||:|||.::..:..:|:|.::.
  Rat   156 --------------------PLPPTP----EDNRRSFQEPEETLVIALYDYQTNDPQELALRRDE 196

  Fly   368 EYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGC 432
            ||.::|.|:.|||:|:|..|:.||.||:|:..|:...||.||||...:||.:||.||....|||.
  Rat   197 EYYLLDSSEIHWWRVQDKNGHEGYAPSSYLVEKSPNSLETYEWYNKSISRDKAEKLLLDTGKEGA 261

  Fly   433 FVVRKSSTKGLYTLSLHTKVPQSH----VKHYHIKQ--NARCEYYLSEKHCCETIPDLINYHRHN 491
            |:||.|.|.|.||:|:.||...|.    :||||||:  ::...||::||:..::||.||.||::|
  Rat   262 FMVRDSRTPGTYTVSVFTKAIISENNPCIKHYHIKETNDSPKRYYVAEKYVFDSIPLLIQYHQYN 326

  Fly   492 SGGLACRLKSSPCD--RPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVK 554
            .|||..||:...|.  :..|.||||.:.||.|.|.||..::|:||||||:|..|.|......|:|
  Rat   327 GGGLVTRLRYPVCSWRQKAPVTAGLRYGKWVIQPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIK 391

  Fly   555 MMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHE----- 614
            .::||.|||:||||||:||.||.||.||||||||.:..||.:|.|:|:||.|.:|||...     
  Rat   392 TIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFAA 456

  Fly   615 KTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTS 679
            :||:|       ||:.|.:||.|||:...|||||||||||||...|:||:|||:.|:||||||||
  Rat   457 ETLLG-------MCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTS 514

  Fly   680 SGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEK 744
            |.|||||:|||.|||.:::|:|||||||::||||||:|:.||:||....|:||||.:..|..|.|
  Rat   515 STGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYK 579

  Fly   745 PKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQ 782
            |:..:..:|.||..||...||:||.|..|:.|||.:|:
  Rat   580 PRLASPHVYQVMNHCWKEKPEDRPPFSRLLSQLAEIAE 617

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Btk29ANP_001097121.1 PH_Btk 44..222 CDD:269944 46/173 (27%)
SH3_Tec_like 346..399 CDD:212702 22/52 (42%)
SH2_Tec_family 403..505 CDD:198188 49/107 (46%)
PTKc_Tec_like 521..778 CDD:173637 143/261 (55%)
Pkinase_Tyr 526..777 CDD:285015 139/255 (55%)
ItkNP_001102295.2 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 318 1.000 Domainoid score I1219
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 572 1.000 Inparanoid score I1017
OMA 1 1.010 - - QHG52659
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000006
OrthoInspector 1 1.000 - - otm46240
orthoMCL 1 0.900 - - OOG6_102306
Panther 1 1.100 - - LDO PTHR24418
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X592
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1211.830

Return to query results.
Submit another query.