Protein Alignment Btk and fgfr2

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_068081038.1
• Gene: fgfr2 / 352940
• ZFINID: ZDB-GENE-030323-1
• Length: 840
• Species: Danio rerio
• Alignment Length: 312
• Identity: 110/312 - (35%)
• Similarity: 168/312 - (53%)
• Gaps: 25/312 - (8%)

  Fly   500 KSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVV--------RRGKWRGSIDTAVKMM 556
            :||..|.|:|........:||....:|.|.:.||.|.||.|        .:.|.:.::..||||:
Zfish   474 RSSAHDDPIPEYDLPEDPRWEFSRDKLTLGKPLGEGCFGQVVMAEALGIDKDKPKEAVTVAVKML 538

  Fly   557 KEGTMSED--DFIEEAKVMTKL-QHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLR------- 611
            |:....:|  |.:.|.::|..: :|.|::.|.|.|::..|:|::.||...|:|..|||
Zfish   539 KDDATEKDLSDLVSEMEMMKMIGRHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGM 603

  Fly   612 --RHEKTLIGNMGL----LLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLAR 670
              .::...:.:..|    |:....||::||.||.....|||||||||.||...||:|:|||||||
Zfish   604 EYSYDIARVSDEPLTFKDLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNVMKIADFGLAR 668

  Fly   671 YVLD-DQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVE 734
            .|.: |.|..:...:.|:||..||.|....::.:||||::|||||||||.|..||..:...|:.:
Zfish   669 DVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFK 733

  Fly   735 RVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQTLTD 786
            .::.|..::||.:|..|:|.:||.||......||.|:.|::.|..:....|:
Zfish   734 LLKEGHRMDKPANCTNELYMMMKDCWHAISSHRPTFKQLVEDLDRILTLATN 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188	2/4 (50%)
		PTKc_Tec_like	521..778	CDD:173637	101/281 (36%)
fgfr2	XP_068081038.1	Ig	56..148	CDD:472250
		Ig strand B	82..86	CDD:409353
		Ig strand E	114..118	CDD:409353
		Ig strand F	128..133	CDD:409353
		Ig strand G	141..144	CDD:409353
		IgI_2_FGFR	177..271	CDD:409443
		Ig strand A	177..180	CDD:409443
		Ig strand A'	188..193	CDD:409443
		Ig strand B	197..205	CDD:409443
		Ig strand C	211..216	CDD:409443
		Ig strand C'	219..221	CDD:409443
		Ig strand D	230..233	CDD:409443
		Ig strand E	237..242	CDD:409443
		Ig strand F	251..258	CDD:409443
		Ig strand G	261..271	CDD:409443
		IgI_3_FGFR2	279..383	CDD:409444
		Ig strand A	279..282	CDD:409444
		Ig strand A'	286..290	CDD:409444
		Ig strand B	298..305	CDD:409444
		Ig strand C	309..316	CDD:409444
		Ig strand D	331..336	CDD:409444
		Ig strand E	348..353	CDD:409444
		Ig strand F	361..369	CDD:409444
		Ig strand G	372..380	CDD:409444
		PTKc_FGFR2	475..787	CDD:270679	110/311 (35%)