Protein Alignment Btk and CG10702

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_724157.1
• Gene: CG10702 / 35181
• FlyBaseID: FBgn0032752
• Length: 946
• Species: Drosophila melanogaster
• Alignment Length: 570
• Identity: 99/570 - (17%)
• Similarity: 186/570 - (32%)
• Gaps: 187/570 - (32%)

  Fly   216 GCRAAAHW------REANNNPSNGSSPAQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLG 274
            ||.::..|      |..|.|.:|   |..|.      |:.........::|||......|..||
  Fly   181 GCSSSHCWSNHYCQRSINENVAN---PKANI------NACHEECLGGCKNNSSSPADCSVCRGL- 235

  Fly   275 GGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPT-----LLNG---NGTLLDANMPGGIPTPG 331
                       ...|.|..:..:.:..:..:::..|     |.:|   :|:...|..|.|..|
  Fly   236 -----------SDDGVCVKSCPKDKYVMENYQRCYTKAECVLKHGYVISGSQCVAFCPSGYKT-- 287

  Fly   332 TPNSKAK-----DNSHFVKLVVALYPFKAIEGGDLSLEKNAE-------------YEVIDDSQ-- 376
              |::::     .:...:......:|.||....:|:..:|..             ...::::|
  Fly   288 --NNRSECVLCSPDEACISFCTPEWPGKAFTVYNLADAENLRGCQIFNGSLVITIRNKVNETQLY 350

  Fly   377 EHWWKVKDALGNVGYIPSNYVKP-KALLGLERYEWYVGDMSRQRAESLLKQGDKE---------- 430
            :.:..:::..|:|....|:.::. :.|..|||..   ||....|..|.:...:||
  Fly   351 QSFTSMREVRGHVKVYRSSQLRSLQFLRNLERVH---GDPLENRHYSFILYDNKELSELWTPSRQ 412

  Fly   431 ------GCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHI-------KQNARC-----EYYLSEKHC 477
                  |.|:.|.:.     ..:...:..|:.|.|...       .|..:|     :.|:.::
  Fly   413 LEFMEGGMFMHRNNK-----LCNRRMREFQNAVTHDRALDSLQTNDQEVQCSPLKLQLYVQKR-- 470

  Fly   478 CETIPDLINYHRHNSGGLACRLKSSPCD------RPVPPTAGLSHDKWEIHPMELMLMEELGSGQ 536
                       .|.|..|:. |||....      ||:.| ..|.|::.|:              .
  Fly   471 -----------THRSVKLSW-LKSQTSQKIELIHRPLLP-GKLYHEESEL--------------D 508

  Fly   537 FGVVRRGKWRGSIDTAVKMMKEGT---MSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRP----- 593
            ..:..|..|:..:.....:::.||   ...||...:.:.:.      |::.:|....|..
  Fly   509 APICTRINWKRRLLFPDDLIENGTHYLFDLDDLQPDTRYVV------LLRTFGNDEAHEAYEARS 567

  Fly   594 --IYIVTEY-MKHGSLLNYLRRHEKTLIGNM------GLLLDMCIQVSKGMTYLERHNYIHR--- 646
              .|:.||. :....||..:::.:.:|...|      ..||.: .::|....|:|:.||.|:
  Fly   568 ELTYVQTELDIPKPPLLELVKKTDSSLTVQMASHDHVSFLLTV-FELSDDQDYIEQRNYCHQPSY 631

  Fly   647 -----------------DLAARNCLVGSENVVKVADFGLARYVLD--DQY 677
                             |..|:          |...|..:|::.|  :||
  Fly   632 VWQDMDGPRWMAYEDYDDCCAQ----------KAEQFEDSRFIADMREQY 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	2/5 (40%)
		SH3_Tec_like	346..399	CDD:212702	9/67 (13%)
		SH2_Tec_family	403..505	CDD:198188	24/129 (19%)
		PTKc_Tec_like	521..778	CDD:173637	32/196 (16%)
CG10702	NP_724157.1	Recep_L_domain	47..159	CDD:460032
		Furin-like	171..297	CDD:395614	27/140 (19%)
		Recep_L_domain	328..441	CDD:460032	18/120 (15%)