DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and Ror

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_476962.1 Gene:Ror / 34367 FlyBaseID:FBgn0010407 Length:685 Species:Drosophila melanogaster


Alignment Length:418 Identity:124/418 - (29%)
Similarity:210/418 - (50%) Gaps:27/418 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly   379 W-WKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLL---KQGDKEGCFVVRKSS 439
            | |.:|:.......|..||.:...  .:|...|...|.||:|...|.   |..||....:|..::
  Fly   261 WSWLMKEISDFPELIGQNYCRNPG--SVENSPWCFVDSSRERIIELCDIPKCADKIWIAIVGTTA 323

  Fly   440 TKGLYTLSLHTKV--PQSHVKHYHIKQNARCEYYLSEKHCC--ETIPDLINYHRHNSGGLA--CR 498
            ...|..:.:...:  .:..:.||.::.........::|:..  ..:.:..:..|.|.|.|:  ..
  Fly   324 AIILIFIIIFAIILFKRRTIMHYGMRNIHNINTPSADKNIYGNSQLNNAQDAGRGNLGNLSDHVA 388

  Fly   499 LKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKW----RGSIDTAVKMMKE- 558
            |.|...:|    ...|..:.:.:..:|  .:||||.|.||.|.:|:.    :.:|..|:|.:|| 
  Fly   389 LNSKLIER----NTLLRINHFTLQDVE--FLEELGEGAFGKVYKGQLLQPNKTTITVAIKALKEN 447

  Fly   559 -GTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMG 622
             ...::.||..|.::::.|:|.|:|.:.||.....|..::.|||.:|.|..:|..:..|...::.
  Fly   448 ASVKTQQDFKREIELISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNSPTEGKSLS 512

  Fly   623 LL--LDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVL-DDQYTSSGGTK 684
            .|  |.:.:|:|:||.||..|:|:|||||||||||....|||::||||:|.:. .|.|.....:.
  Fly   513 QLEFLQIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSDYYRVQSKSL 577

  Fly   685 FPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCA 749
            .|::|.|.|.:.|.:|:::||||::||::|||::.|..||....|.||:..::...:|..|::|.
  Fly   578 LPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLSAPENCP 642

  Fly   750 KEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            ..:|.:|..||.....:||.|..:.::|
  Fly   643 TAVYSLMIECWHEQSVKRPTFTDISNRL 670

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 6/20 (30%)
SH2_Tec_family 403..505 CDD:198188 21/110 (19%)
PTKc_Tec_like 521..778 CDD:173637 95/266 (36%)
RorNP_476962.1 CRD_TK_ROR_like 39..228 CDD:143568
KR 235..312 CDD:214527 14/52 (27%)
PTKc_Ror 404..673 CDD:270642 95/269 (35%)
Blue background indicates that the domain is not in the aligned region.

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