Protein Alignment Btk and yrk

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_001352482.1
• Gene: yrk / 337571
• ZFINID: ZDB-GENE-030131-9517
• Length: 528
• Species: Danio rerio
• Alignment Length: 573
• Identity: 209/573 - (36%)
• Similarity: 307/573 - (53%)
• Gaps: 74/573 - (12%)

  Fly   216 GCRAAAHWREANNNPSN-GSSPAQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSL 279
            || |....|:|:...|| .|..|.|.|::..|:....:..|:
Zfish     2 GC-ACCKQRKASKAVSNQNSCDAFNGTQASEPSRYIPDPTFN----------------------- 42

  Fly   280 GLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFV 344
                                |.:..|......|....::::...|.|:...|            |
Zfish    43 --------------------SGIPNFNDFSNPLTPPTSIINPARPPGLTGGG------------V 75

  Fly   345 KLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDA-LGNVGYIPSNYVKPKALLGLERY 408
            .|.:|||.:.|....|||.:|..::.:|::::..||:.:.. .|..||||||||.|  :..::..
Zfish    76 TLFIALYEYDARTEDDLSFQKGEKFHIINNTEGDWWEARSLDTGKSGYIPSNYVAP--VDSIQAE 138

  Fly   409 EWYVGDMSRQRAE-SLLKQGDKEGCFVVRKS-STKGLYTLSLH--TKVPQSHVKHYHIKQNARCE 469
            |||.|.|.|:.|| .||.|.:..|.|::|:| :|||.|:||:.  ......|||||.|::.....
Zfish   139 EWYFGKMGRKDAERQLLAQNNPRGTFLIRESETTKGAYSLSIRDWDDAKGDHVKHYKIRKLDNGG 203

  Fly   470 YYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLS---HDKWEIHPMELMLMEE 531
            ||::.:...:|:..|:.::...:.||.|||..| |.|.:|..|.||   .|.|||....|.|:::
Zfish   204 YYITTRTQFDTVQQLVEHYTERAAGLCCRLIGS-CRRGMPKLADLSVKTKDVWEIPRESLQLIKK 267

  Fly   532 LGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYI 596
            ||:||||.|..|.|.|:...|||.:|.||||.:.|::||::|.:|:|..|||||.|.|: .||||
Zfish   268 LGNGQFGEVWMGMWNGTTKVAVKTLKPGTMSPEAFLDEAQIMKRLRHDKLVQLYAVVSE-EPIYI 331

  Fly   597 VTEYMKHGSLLNYLRRHEKTLIGNMGL--LLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSEN 659
            :||:|..||||::|:..:..   |:.|  |:||..|::.||.|:||.|||||||.|.|.|||...
Zfish   332 ITEFMSQGSLLDFLKDGDGR---NLKLPQLVDMAAQIAAGMAYIERMNYIHRDLRAANILVGDGL 393

  Fly   660 VVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPY 724
            |.|:|||||||.:.|::||:..|.||||||..||...|.:|:.|||||::|:|:.|:.|.|::||
Zfish   394 VCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGKFTIKSDVWSFGILLTELITKGRVPY 458

  Fly   725 GRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            ..:.|.||:|:|:||..:..|:.....::::|..||...|:||..|..|...|
Zfish   459 PGMNNREVLEQVERGYRMPCPQGSPASLHELMLQCWRKDPDERHTFEYLQSFL 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	3/5 (60%)
		SH3_Tec_like	346..399	CDD:212702	21/53 (40%)
		SH2_Tec_family	403..505	CDD:198188	37/105 (35%)
		PTKc_Tec_like	521..778	CDD:173637	121/259 (47%)
yrk	NP_001352482.1	SH3	76..133	CDD:473055	22/58 (38%)
		SH2	136..234	CDD:472789	35/97 (36%)
		PTKc_Src_Fyn_like	266..513	CDD:271105	118/250 (47%)