Protein Alignment Btk and src

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_017209008.1
• Gene: src / 325084
• ZFINID: ZDB-GENE-030131-3809
• Length: 549
• Species: Danio rerio
• Alignment Length: 528
• Identity: 208/528 - (39%)
• Similarity: 295/528 - (55%)
• Gaps: 48/528 - (9%)

  Fly   278 SLGLGGGGGGGGSCTPTSLQPQSSL----TTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAK 338
            ||..|.||....:..|||..|..|.    :.....|.::|....|.     ||:.:  |.||...
Zfish    17 SLDDGTGGHHHHTPNPTSFTPNRSPPVEGSRRGTQPNIINAEQALF-----GGVNS--TTNSITS 74

  Fly   339 DNS----HFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQE------HWWKVKD-ALGNVGYI 392
            .|.    ..|...||||.:::....|||..|....::::::::      .||..:. ..|..|||
Zfish    75 PNRIGILGGVTTFVALYDYESRTASDLSFRKGERLQIVNNTRKLNPREGDWWLARSLTTGESGYI 139

  Fly   393 PSNYVKPKALLGLERY-------EWYVGDMSRQRAES-LLKQGDKEGCFVVRKS-STKGLYTLSL 448
            |||||.|...:..|.:       .||.|.::|:.:|. ||...::.|.|:||:| :|||.|.||:
Zfish   140 PSNYVAPSDSIQAEDHLRLTLEKRWYFGKITRRDSERLLLNLENRRGTFLVRESETTKGAYCLSV 204

  Fly   449 --HTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPT 511
              :..|...:||||.|::.....:|::.:....|:..|:|::|.::.|| |...:..|....|||
Zfish   205 LDYDNVKGLNVKHYKIRKLDSGGFYITSRTQFSTLQQLVNHYRQHADGL-CHSLTDVCPVLKPPT 268

  Fly   512 AGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKL 576
            .||:.|.|||....|.|..:||.|.||.|..|.|.|:...|:|.:|.||||.:.|::||:||.||
Zfish   269 QGLARDAWEIPRDSLRLDVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKL 333

  Fly   577 QHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLL------DMCIQVSKGM 635
            :|..|||||.|.|: .|||||||||..||||::|:       |:||.:|      ||..|::.||
Zfish   334 RHEKLVQLYAVVSE-EPIYIVTEYMGQGSLLDFLK-------GDMGKMLRLPQLVDMASQIASGM 390

  Fly   636 TYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRF 700
            .|:||.||:||||.|.|.|||...|.|||||||||.:.|::||:..|.||||||..||...|.||
Zfish   391 AYVERMNYVHRDLRAANILVGDNLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 455

  Fly   701 SSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPE 765
            :.|||||::|:|:.|:.|.|::||..:.|.||:::|:||..:..|..|...::::|..||...||
Zfish   456 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPAECPDSLHELMLTCWRKEPE 520

  Fly   766 ERPAFRVL 773
            |||.|..|
Zfish   521 ERPTFEYL 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	19/59 (32%)
		SH2_Tec_family	403..505	CDD:198188	33/112 (29%)
		PTKc_Tec_like	521..778	CDD:173637	126/259 (49%)
src	XP_017209008.1	SH3	85..148	CDD:473055	20/62 (32%)
		SH2_Src_Src	162..260	CDD:198228	32/98 (33%)
		PTKc_Src	273..549	CDD:270656	129/264 (49%)